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Vascular endothelial growth factor is a strong predictor of early distant recurrences in a prospective study of premenopausal women with lymph-node negative breast cancer

Linderholm, Barbro K.; Gruvberger, Sofia LU ; Fernö, Mårten LU ; Bendahl, Pär-Ola LU and Malmström, Per LU (2008) In Breast 17(5). p.484-491
Abstract
We investigate the prognostic significance of the pro-angiogenic cytokine vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and S-phase fraction (SPF) for distant disease free survival (DDFS) in 219 premenopausal patients with node-negative breast cancer (NNBC). In univariate analysis significantly shorter DDFS was observed for patients with high VEGF (p = 0.006), high uPA (p = 0.001). and high SPF (p < 0.001). The prognostic significance of VEGF varied over time being very, strong for early relapses (0-2.25 years follow-up) (HR = 7.9: p = 0.006) while no difference was seen in the subsequent follow-up period (HR = 1.3: p = 0.62). In a series of bivariate... (More)
We investigate the prognostic significance of the pro-angiogenic cytokine vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and S-phase fraction (SPF) for distant disease free survival (DDFS) in 219 premenopausal patients with node-negative breast cancer (NNBC). In univariate analysis significantly shorter DDFS was observed for patients with high VEGF (p = 0.006), high uPA (p = 0.001). and high SPF (p < 0.001). The prognostic significance of VEGF varied over time being very, strong for early relapses (0-2.25 years follow-up) (HR = 7.9: p = 0.006) while no difference was seen in the subsequent follow-up period (HR = 1.3: p = 0.62). In a series of bivariate analyses VEGF provided prognostic information during the whole observation period (0-72 months) in addition to age, tumor size, oestrogen receptor (ER), progesterone receptor (PgR), and uPA. Also this effect was more pronounced during the first follow-up period suggesting VEGF as a marker of early recurrences. (C) 2008 Elsevier Ltd. All rights reserved. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
Early relapses, S-phase fraction (SPF), activator (uPA), Vascular endothelial growth factor (VEGF), Urokinase-type plasminogen, Premenopausal, lymph node-negative breast cancer
in
Breast
volume
17
issue
5
pages
484 - 491
publisher
Churchill Livingstone
external identifiers
  • wos:000260896700009
  • scopus:53149153529
ISSN
1532-3080
DOI
10.1016/j.breast.2008.02.010
language
English
LU publication?
yes
id
09e3c7cc-73e5-4695-842a-47074423b811 (old id 1283652)
date added to LUP
2009-02-10 10:19:47
date last changed
2017-06-18 03:59:44
@article{09e3c7cc-73e5-4695-842a-47074423b811,
  abstract     = {We investigate the prognostic significance of the pro-angiogenic cytokine vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and S-phase fraction (SPF) for distant disease free survival (DDFS) in 219 premenopausal patients with node-negative breast cancer (NNBC). In univariate analysis significantly shorter DDFS was observed for patients with high VEGF (p = 0.006), high uPA (p = 0.001). and high SPF (p &lt; 0.001). The prognostic significance of VEGF varied over time being very, strong for early relapses (0-2.25 years follow-up) (HR = 7.9: p = 0.006) while no difference was seen in the subsequent follow-up period (HR = 1.3: p = 0.62). In a series of bivariate analyses VEGF provided prognostic information during the whole observation period (0-72 months) in addition to age, tumor size, oestrogen receptor (ER), progesterone receptor (PgR), and uPA. Also this effect was more pronounced during the first follow-up period suggesting VEGF as a marker of early recurrences. (C) 2008 Elsevier Ltd. All rights reserved.},
  author       = {Linderholm, Barbro K. and Gruvberger, Sofia and Fernö, Mårten and Bendahl, Pär-Ola and Malmström, Per},
  issn         = {1532-3080},
  keyword      = {Early relapses,S-phase fraction (SPF),activator (uPA),Vascular endothelial growth factor (VEGF),Urokinase-type plasminogen,Premenopausal,lymph node-negative breast cancer},
  language     = {eng},
  number       = {5},
  pages        = {484--491},
  publisher    = {Churchill Livingstone},
  series       = {Breast},
  title        = {Vascular endothelial growth factor is a strong predictor of early distant recurrences in a prospective study of premenopausal women with lymph-node negative breast cancer},
  url          = {http://dx.doi.org/10.1016/j.breast.2008.02.010},
  volume       = {17},
  year         = {2008},
}