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Sustained postprandial decrease in plasma levels of LDL cholesterol in patients with type-2 diabetes mellitus

Lund, S. S.; Petersen, M.; Frandsen, M.; Smidt, U. M.; Parving, H. -H.; Vaag, Allan LU and Jensen, T. (2008) In Scandinavian Journal of Clinical & Laboratory Investigation 68(7). p.628-640
Abstract
Objective . Low density lipoprotein cholesterol (LDL-C) is an independent and modifiable risk factor for development of cardiovascular disease (CVD). Postprandial lipid metabolism has been linked to CVD, but little is known about the postprandial LDL-C profile in patients with type-2 diabetes (T2DM). We aimed to study the postprandial levels of LDL-C in T2DM patients. Material and methods . After an overnight fast, 74 T2DM patients, mean age approximately 60 years, were served a standard fat-rich meal of 3,515 kJ containing 54 % fat, 13 % protein and 33 % carbohydrates. Only drinking water was allowed postprandially. Blood samples were drawn at times 0 (fasting), 1.5, 3.0, 4.5 and 6.0 h (postprandial). In all samples, LDL-C was measured... (More)
Objective . Low density lipoprotein cholesterol (LDL-C) is an independent and modifiable risk factor for development of cardiovascular disease (CVD). Postprandial lipid metabolism has been linked to CVD, but little is known about the postprandial LDL-C profile in patients with type-2 diabetes (T2DM). We aimed to study the postprandial levels of LDL-C in T2DM patients. Material and methods . After an overnight fast, 74 T2DM patients, mean age approximately 60 years, were served a standard fat-rich meal of 3,515 kJ containing 54 % fat, 13 % protein and 33 % carbohydrates. Only drinking water was allowed postprandially. Blood samples were drawn at times 0 (fasting), 1.5, 3.0, 4.5 and 6.0 h (postprandial). In all samples, LDL-C was measured with modified beta quantification (separation by ultracentrifugation followed by measurement of infranate high density lipoprotein cholesterol (HLD-C) using a homogeneous assay). Results . At all postprandial times, levels of LDL-C showed highly significant (p<0.005) decreases compared to time 0 (mean [95 % CI] maximum change in LDL-C levels at 3.0 h: -0.16 mmol/L [-0.12; -0.20]; p<0.001). Independently of fasting LDL-C levels and ongoing statin therapy, LDL-C decreased significantly more in female compared to male patients postprandially (mean [95 % CI] maximum unadjusted change versus time 0 in LDL-C for men [n=56] at 3.0 h: -0.14 mmol/L [-0.19; -0.10], p<0.001; for women [n=18] at 4.5 h: -0.26 mmol/L [-0.35; -0.18], p<0.001; -0.14 mmol/L [-0.24; -0.05], p=0.005 between genders for the mean [95 % CI] fasting adjusted difference at 4.5 h in the change versus time 0 in LDL-C; gender by time interaction: p=0.007 (repeated measures mixed model)). Conclusions . In T2DM patients served a fat-rich meal, levels of LDL-C decreased significantly more in women compared to men postprandially, irrespective of fasting levels or ongoing statin therapy. This might have implications in the atherosclerotic process and on any difference in the risk of CVD between genders. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
density lipoprotein cholesterol (LDL-C), low, lipoproteins, hydroxymethylglutaryl-CoA reductase inhibitors, gender, fasting, Cholesterol, diabetes mellitus type-2, ultracentrifugation, statins, postprandial period
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
68
issue
7
pages
628 - 640
publisher
Informa Healthcare
external identifiers
  • wos:000260497100018
  • scopus:55249119842
ISSN
1502-7686
DOI
10.1080/00365510801995736
language
English
LU publication?
yes
id
f6d3293c-a7cf-44f8-b761-3bf78e0e7c5c (old id 1284121)
date added to LUP
2009-02-09 10:15:56
date last changed
2017-01-01 06:33:57
@article{f6d3293c-a7cf-44f8-b761-3bf78e0e7c5c,
  abstract     = {Objective . Low density lipoprotein cholesterol (LDL-C) is an independent and modifiable risk factor for development of cardiovascular disease (CVD). Postprandial lipid metabolism has been linked to CVD, but little is known about the postprandial LDL-C profile in patients with type-2 diabetes (T2DM). We aimed to study the postprandial levels of LDL-C in T2DM patients. Material and methods . After an overnight fast, 74 T2DM patients, mean age approximately 60 years, were served a standard fat-rich meal of 3,515 kJ containing 54 % fat, 13 % protein and 33 % carbohydrates. Only drinking water was allowed postprandially. Blood samples were drawn at times 0 (fasting), 1.5, 3.0, 4.5 and 6.0 h (postprandial). In all samples, LDL-C was measured with modified beta quantification (separation by ultracentrifugation followed by measurement of infranate high density lipoprotein cholesterol (HLD-C) using a homogeneous assay). Results . At all postprandial times, levels of LDL-C showed highly significant (p&lt;0.005) decreases compared to time 0 (mean [95 % CI] maximum change in LDL-C levels at 3.0 h: -0.16 mmol/L [-0.12; -0.20]; p&lt;0.001). Independently of fasting LDL-C levels and ongoing statin therapy, LDL-C decreased significantly more in female compared to male patients postprandially (mean [95 % CI] maximum unadjusted change versus time 0 in LDL-C for men [n=56] at 3.0 h: -0.14 mmol/L [-0.19; -0.10], p&lt;0.001; for women [n=18] at 4.5 h: -0.26 mmol/L [-0.35; -0.18], p&lt;0.001; -0.14 mmol/L [-0.24; -0.05], p=0.005 between genders for the mean [95 % CI] fasting adjusted difference at 4.5 h in the change versus time 0 in LDL-C; gender by time interaction: p=0.007 (repeated measures mixed model)). Conclusions . In T2DM patients served a fat-rich meal, levels of LDL-C decreased significantly more in women compared to men postprandially, irrespective of fasting levels or ongoing statin therapy. This might have implications in the atherosclerotic process and on any difference in the risk of CVD between genders.},
  author       = {Lund, S. S. and Petersen, M. and Frandsen, M. and Smidt, U. M. and Parving, H. -H. and Vaag, Allan and Jensen, T.},
  issn         = {1502-7686},
  keyword      = {density lipoprotein cholesterol (LDL-C),low,lipoproteins,hydroxymethylglutaryl-CoA reductase inhibitors,gender,fasting,Cholesterol,diabetes mellitus type-2,ultracentrifugation,statins,postprandial period},
  language     = {eng},
  number       = {7},
  pages        = {628--640},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Sustained postprandial decrease in plasma levels of LDL cholesterol in patients with type-2 diabetes mellitus},
  url          = {http://dx.doi.org/10.1080/00365510801995736},
  volume       = {68},
  year         = {2008},
}