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Apolipoprotein M: structure and function

Dahlbäck, Björn LU ; Ahnström, Josefin LU ; Christoffersen, Christina and Nielsen, Lars Bo (2008) In Future Lipidology 3(5). p.495-503
Abstract
Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C is considered to be protective against development of atherosclerosis. Apolipoproteins Al and B are the major proteins of HDL and LDL, respectively. In HDL, a large number of additional proteins with important functions... (More)
Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C is considered to be protective against development of atherosclerosis. Apolipoproteins Al and B are the major proteins of HDL and LDL, respectively. In HDL, a large number of additional proteins with important functions have been identified. A late addition to the list of HDL-associated proteins is apoM, the structure and function of which are the topic of this review. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lipoproteins, lipocalin, LDL, HNF-1 alpha, HDL, Foxa2, atherosclerosis, diabetes, LRH-1, megalin, MODY3, PON-1
in
Future Lipidology
volume
3
issue
5
pages
495 - 503
publisher
Future Medicine Ltd.
external identifiers
  • wos:000260284200008
  • scopus:55849106683
ISSN
1746-0875
DOI
10.2217/17460875.3.5.495
language
English
LU publication?
yes
id
9afd2e56-9439-4b1b-87e0-ebbeec4fd322 (old id 1284695)
date added to LUP
2009-02-09 09:14:32
date last changed
2017-01-01 06:03:00
@article{9afd2e56-9439-4b1b-87e0-ebbeec4fd322,
  abstract     = {Lipoproteins in blood play an important physiological role transporting cholesterol, lipids and lipid-soluble substances to the different organs of the body. Diseases such as atherosclerosis, cardiovascular disease and stroke are associated with defects in lipoprotein metabolism. For many years, intense research has focused on the role of cholesterol in development of atherosclerosis. Cholesterol is transported in both LDL and HDL; increased concentrations of LDL-C are associated with atherosclerosis, whereas high HDL-C is considered to be protective against development of atherosclerosis. Apolipoproteins Al and B are the major proteins of HDL and LDL, respectively. In HDL, a large number of additional proteins with important functions have been identified. A late addition to the list of HDL-associated proteins is apoM, the structure and function of which are the topic of this review.},
  author       = {Dahlbäck, Björn and Ahnström, Josefin and Christoffersen, Christina and Nielsen, Lars Bo},
  issn         = {1746-0875},
  keyword      = {lipoproteins,lipocalin,LDL,HNF-1 alpha,HDL,Foxa2,atherosclerosis,diabetes,LRH-1,megalin,MODY3,PON-1},
  language     = {eng},
  number       = {5},
  pages        = {495--503},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Lipidology},
  title        = {Apolipoprotein M: structure and function},
  url          = {http://dx.doi.org/10.2217/17460875.3.5.495},
  volume       = {3},
  year         = {2008},
}