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A novel fusion 5 ' AFF3/3 ' BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma

Impera, L.; Albano, F.; Lo Cunsolo, C.; Funes, S.; Iuzzolino, P.; Laveder, F.; Panagopoulos, Ioannis LU ; Rocchi, M. and Storlazzi, C. T. (2008) In Oncogene 27(47). p.6187-6190
Abstract
Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categories: (i) simple variants, involving chromosomes 18 and 2, or 22, in which the fusion partner of BCL2 is the light-chain IGK@ or IGL@; (ii) complex variant translocations occurring among chromosomes 14, 18 and other chromosomes. We report a follicular lymphoma case showing BCL2 overexpression, detected by immunohistochemistry and real-time... (More)
Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categories: (i) simple variants, involving chromosomes 18 and 2, or 22, in which the fusion partner of BCL2 is the light-chain IGK@ or IGL@; (ii) complex variant translocations occurring among chromosomes 14, 18 and other chromosomes. We report a follicular lymphoma case showing BCL2 overexpression, detected by immunohistochemistry and real-time quantitative PCR, consequently to the formation of a novel fusion gene between the 5' of the lymphoid nuclear transcriptional activator gene AFF3 at 2q11.2, and the 3' of BCL2. This case shows evidence, for the first time, of BCL2 overexpression consequently to the fusion of BCL2 to a non-IG partner locus. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
translocation, follicular lymphoma, fusion gene, AFF3, BCL2
in
Oncogene
volume
27
issue
47
pages
6187 - 6190
publisher
Nature Publishing Group
external identifiers
  • wos:000260083100011
  • scopus:54049092768
ISSN
1476-5594
DOI
10.1038/onc.2008.214
language
English
LU publication?
yes
id
7218eeef-2547-4024-b60b-fcfc5178001c (old id 1284881)
date added to LUP
2009-02-06 11:24:06
date last changed
2017-10-01 03:34:39
@article{7218eeef-2547-4024-b60b-fcfc5178001c,
  abstract     = {Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categories: (i) simple variants, involving chromosomes 18 and 2, or 22, in which the fusion partner of BCL2 is the light-chain IGK@ or IGL@; (ii) complex variant translocations occurring among chromosomes 14, 18 and other chromosomes. We report a follicular lymphoma case showing BCL2 overexpression, detected by immunohistochemistry and real-time quantitative PCR, consequently to the formation of a novel fusion gene between the 5' of the lymphoid nuclear transcriptional activator gene AFF3 at 2q11.2, and the 3' of BCL2. This case shows evidence, for the first time, of BCL2 overexpression consequently to the fusion of BCL2 to a non-IG partner locus.},
  author       = {Impera, L. and Albano, F. and Lo Cunsolo, C. and Funes, S. and Iuzzolino, P. and Laveder, F. and Panagopoulos, Ioannis and Rocchi, M. and Storlazzi, C. T.},
  issn         = {1476-5594},
  keyword      = {translocation,follicular lymphoma,fusion gene,AFF3,BCL2},
  language     = {eng},
  number       = {47},
  pages        = {6187--6190},
  publisher    = {Nature Publishing Group},
  series       = {Oncogene},
  title        = {A novel fusion 5 ' AFF3/3 ' BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma},
  url          = {http://dx.doi.org/10.1038/onc.2008.214},
  volume       = {27},
  year         = {2008},
}