Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma
(2008) In Blood 112(9). p.3582-3586- Abstract
- Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P <.01). Compared with the entire study... (More)
- Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P <.01). Compared with the entire study population, the relative risk (RR) of DVT after a diagnosis of MGUS and MM was 3.3 (95% confidence interval [CI], 2.3-4.7) and 9.2 ( 95% CI, 7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year after diagnosis of MGUS ( RR = 8.4; 95% CI, 5.7-12.2) and MM ( RR = 11.6; 95% CI, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. (Blood. 2008; 112: 3582-3586) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1284987
- author
- Kristinsson, Sigurdur Y. ; Fears, Thomas R. ; Gridley, Gloria ; Turesson, Ingemar LU ; Mellqvist, Ulf-Henrik ; Bjoerkholm, Magnus and Landgren, Ola
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 112
- issue
- 9
- pages
- 3582 - 3586
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000260301800016
- scopus:55749097953
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2008-04-151076
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 4124ae6c-2192-4266-96c5-313912b09c28 (old id 1284987)
- date added to LUP
- 2016-04-01 11:49:03
- date last changed
- 2022-05-14 05:26:14
@article{4124ae6c-2192-4266-96c5-313912b09c28, abstract = {{Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P <.01). Compared with the entire study population, the relative risk (RR) of DVT after a diagnosis of MGUS and MM was 3.3 (95% confidence interval [CI], 2.3-4.7) and 9.2 ( 95% CI, 7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year after diagnosis of MGUS ( RR = 8.4; 95% CI, 5.7-12.2) and MM ( RR = 11.6; 95% CI, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. (Blood. 2008; 112: 3582-3586)}}, author = {{Kristinsson, Sigurdur Y. and Fears, Thomas R. and Gridley, Gloria and Turesson, Ingemar and Mellqvist, Ulf-Henrik and Bjoerkholm, Magnus and Landgren, Ola}}, issn = {{1528-0020}}, language = {{eng}}, number = {{9}}, pages = {{3582--3586}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma}}, url = {{http://dx.doi.org/10.1182/blood-2008-04-151076}}, doi = {{10.1182/blood-2008-04-151076}}, volume = {{112}}, year = {{2008}}, }