Advanced

Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma

Kristinsson, Sigurdur Y.; Fears, Thomas R.; Gridley, Gloria; Turesson, Ingemar LU ; Mellqvist, Ulf-Henrik; Bjoerkholm, Magnus and Landgren, Ola (2008) In Blood 112(9). p.3582-3586
Abstract
Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P <.01). Compared with the entire study... (More)
Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P <.01). Compared with the entire study population, the relative risk (RR) of DVT after a diagnosis of MGUS and MM was 3.3 (95% confidence interval [CI], 2.3-4.7) and 9.2 ( 95% CI, 7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year after diagnosis of MGUS ( RR = 8.4; 95% CI, 5.7-12.2) and MM ( RR = 11.6; 95% CI, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. (Blood. 2008; 112: 3582-3586) (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
112
issue
9
pages
3582 - 3586
publisher
American Society of Hematology
external identifiers
  • wos:000260301800016
  • scopus:55749097953
ISSN
1528-0020
DOI
10.1182/blood-2008-04-151076
language
English
LU publication?
yes
id
4124ae6c-2192-4266-96c5-313912b09c28 (old id 1284987)
date added to LUP
2009-02-06 11:10:36
date last changed
2017-08-06 03:35:05
@article{4124ae6c-2192-4266-96c5-313912b09c28,
  abstract     = {Patients with multiple myeloma ( MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, 2 small hospital-based studies observed persons with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4 196 197 veterans hospitalized at least once at US Veterans Affairs hospitals, we identified a total of 2374 cases of MGUS, and 39 272 persons were diagnosed with DVT ( crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively ( crude incidence 3.1 and 8.7 per 1000 person-years, respectively; P &lt;.01). Compared with the entire study population, the relative risk (RR) of DVT after a diagnosis of MGUS and MM was 3.3 (95% confidence interval [CI], 2.3-4.7) and 9.2 ( 95% CI, 7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year after diagnosis of MGUS ( RR = 8.4; 95% CI, 5.7-12.2) and MM ( RR = 11.6; 95% CI, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. (Blood. 2008; 112: 3582-3586)},
  author       = {Kristinsson, Sigurdur Y. and Fears, Thomas R. and Gridley, Gloria and Turesson, Ingemar and Mellqvist, Ulf-Henrik and Bjoerkholm, Magnus and Landgren, Ola},
  issn         = {1528-0020},
  language     = {eng},
  number       = {9},
  pages        = {3582--3586},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma},
  url          = {http://dx.doi.org/10.1182/blood-2008-04-151076},
  volume       = {112},
  year         = {2008},
}