Advanced

Sentinel node biopsy in malignant melanoma: Swedish experiences 1997-2005

Mattsson, Jan; Bergkvist, Leif; Abdiu, Avni; Low, J. F. Aili; Naredi, Peter; Ullberg, Karin; Garpered, Ulf; Håkansson, Annika LU and Ingvar, Christian LU (2008) In Acta Oncologica 47(8). p.1519-1525
Abstract
The sentinel node biopsy (SNB) procedure is a multidisciplinary technique, invented to gain prognostic information in different malignant tumors. The aim of the present study was to study the cohort of patients with malignant melanoma, operated with SNB, from the introduction of the technique in Sweden, concerning the prognostic information retrieved and the outcome of the procedures. In Sweden all patients with malignant melanoma are registered at regional Oncological Centers. From these databases ten centers were identified, treating malignant melanoma and performing sentinel node biopsy. Consecutive data concerning tumor characteristics, outcome of the procedure and disease related events during the follow-up time were collected from... (More)
The sentinel node biopsy (SNB) procedure is a multidisciplinary technique, invented to gain prognostic information in different malignant tumors. The aim of the present study was to study the cohort of patients with malignant melanoma, operated with SNB, from the introduction of the technique in Sweden, concerning the prognostic information retrieved and the outcome of the procedures. In Sweden all patients with malignant melanoma are registered at regional Oncological Centers. From these databases ten centers were identified, treating malignant melanoma and performing sentinel node biopsy. Consecutive data concerning tumor characteristics, outcome of the procedure and disease related events during the follow-up time were collected from these ten centers. All cases from the very first in each centre were included. The SNB procedure was performed in 422 patients with a sentinel node (SN) detection rate of 97%, the mean Breslow thickness of the primary tumors was 3.2 mm (median 2.4 mm) and the proportion of ulcerated melanomas 38%. Metastasis in the SN was found in 19% of the patients but there was a wide range in the proportion of SN metastases between the different centers (5-52%). After a follow-up of median 12 months of 361 patients, SN negative patients had better disease-free survival than SN positive (p < 0.0001). A false negative rate of 14% was found during the follow-up time. In this study the surgical technique seemed acceptable, but the non-centralized pathology work-up sub-optimal. However, SNB was still found to be a significant prognostic indicator, concerning disease free survival. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
47
issue
8
pages
1519 - 1525
publisher
Taylor & Francis
external identifiers
  • wos:000260227700007
  • scopus:54349120302
ISSN
1651-226X
DOI
10.1080/02841860701785533
language
English
LU publication?
yes
id
ec1f7eeb-afb5-4371-88c8-646e182e066b (old id 1285083)
date added to LUP
2009-02-06 11:20:11
date last changed
2017-09-03 04:14:55
@article{ec1f7eeb-afb5-4371-88c8-646e182e066b,
  abstract     = {The sentinel node biopsy (SNB) procedure is a multidisciplinary technique, invented to gain prognostic information in different malignant tumors. The aim of the present study was to study the cohort of patients with malignant melanoma, operated with SNB, from the introduction of the technique in Sweden, concerning the prognostic information retrieved and the outcome of the procedures. In Sweden all patients with malignant melanoma are registered at regional Oncological Centers. From these databases ten centers were identified, treating malignant melanoma and performing sentinel node biopsy. Consecutive data concerning tumor characteristics, outcome of the procedure and disease related events during the follow-up time were collected from these ten centers. All cases from the very first in each centre were included. The SNB procedure was performed in 422 patients with a sentinel node (SN) detection rate of 97%, the mean Breslow thickness of the primary tumors was 3.2 mm (median 2.4 mm) and the proportion of ulcerated melanomas 38%. Metastasis in the SN was found in 19% of the patients but there was a wide range in the proportion of SN metastases between the different centers (5-52%). After a follow-up of median 12 months of 361 patients, SN negative patients had better disease-free survival than SN positive (p &lt; 0.0001). A false negative rate of 14% was found during the follow-up time. In this study the surgical technique seemed acceptable, but the non-centralized pathology work-up sub-optimal. However, SNB was still found to be a significant prognostic indicator, concerning disease free survival.},
  author       = {Mattsson, Jan and Bergkvist, Leif and Abdiu, Avni and Low, J. F. Aili and Naredi, Peter and Ullberg, Karin and Garpered, Ulf and Håkansson, Annika and Ingvar, Christian},
  issn         = {1651-226X},
  language     = {eng},
  number       = {8},
  pages        = {1519--1525},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Sentinel node biopsy in malignant melanoma: Swedish experiences 1997-2005},
  url          = {http://dx.doi.org/10.1080/02841860701785533},
  volume       = {47},
  year         = {2008},
}