Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2
(2008) In The Journal of Neuroscience 28(41). p.10187-10199- Abstract
- The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing through capillaries, and can manifest the ability to proliferate and form a long cytoplasmic protuberance. They are attracted in greater numbers during endotoxemia by a combination of vasoregulatory molecules, including TNF (tumor necrosis factor), interleukin-1... (More)
- The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing through capillaries, and can manifest the ability to proliferate and form a long cytoplasmic protuberance. They are attracted in greater numbers during endotoxemia by a combination of vasoregulatory molecules, including TNF (tumor necrosis factor), interleukin-1 beta, and angiopoietin-2. After a period of several hours, some of them cross the endothelium to expand the population of perivascular macrophages. Depletion of adherent monocytes and perivascular macrophages can be achieved by injection of anti-angiopoietin-2 peptide-Fc fusion protein. This study extends our understanding of the behavior of monocytes at the blood-brain interface and provides a way to block their infiltration into the nervous tissue under inflammatory conditions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1285709
- author
- Audoy-Remus, Julie ; Richard, Jean-Francois ; Soulet, Denis LU ; Zhou, Hong ; Kubes, Paul and Vallieres, Luc
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- blood-brain, endothelial, microglia, neuroinflammation, macrophage, barrier, cytokine
- in
- The Journal of Neuroscience
- volume
- 28
- issue
- 41
- pages
- 10187 - 10199
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000259912400002
- scopus:55249088143
- pmid:18842879
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.3510-08.2008
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- beaa6366-f0bf-4dfe-bb40-302efc32cf72 (old id 1285709)
- date added to LUP
- 2016-04-01 14:42:49
- date last changed
- 2023-09-03 18:22:51
@article{beaa6366-f0bf-4dfe-bb40-302efc32cf72,
abstract = {{The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endothelium, these monocytes start to crawl, adopt a rod-shaped morphology when passing through capillaries, and can manifest the ability to proliferate and form a long cytoplasmic protuberance. They are attracted in greater numbers during endotoxemia by a combination of vasoregulatory molecules, including TNF (tumor necrosis factor), interleukin-1 beta, and angiopoietin-2. After a period of several hours, some of them cross the endothelium to expand the population of perivascular macrophages. Depletion of adherent monocytes and perivascular macrophages can be achieved by injection of anti-angiopoietin-2 peptide-Fc fusion protein. This study extends our understanding of the behavior of monocytes at the blood-brain interface and provides a way to block their infiltration into the nervous tissue under inflammatory conditions.}},
author = {{Audoy-Remus, Julie and Richard, Jean-Francois and Soulet, Denis and Zhou, Hong and Kubes, Paul and Vallieres, Luc}},
issn = {{1529-2401}},
keywords = {{blood-brain; endothelial; microglia; neuroinflammation; macrophage; barrier; cytokine}},
language = {{eng}},
number = {{41}},
pages = {{10187--10199}},
publisher = {{Society for Neuroscience}},
series = {{The Journal of Neuroscience}},
title = {{Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2}},
url = {{http://dx.doi.org/10.1523/JNEUROSCI.3510-08.2008}},
doi = {{10.1523/JNEUROSCI.3510-08.2008}},
volume = {{28}},
year = {{2008}},
}