The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy
(2008) In ALTEX Alternatives To Animal Experimentation 25(3). p.163-190- Abstract
- Human embryonic stern cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In all ongoing ethical debate opinions of different groups are based oil varying sets of religious, historical, cultural and scientific arguments as well as oil widely differing levels of general information. We here give all overview of the biological background for non-specialists, and address all issues of the current stern cell debate that are of concern in different cultures and states. Thirty-five chapters address embryo definition, potential killing and the beginning of human life, in addition to matters of human dignity, patenting, commercialisation, and potential... (More)
- Human embryonic stern cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In all ongoing ethical debate opinions of different groups are based oil varying sets of religious, historical, cultural and scientific arguments as well as oil widely differing levels of general information. We here give all overview of the biological background for non-specialists, and address all issues of the current stern cell debate that are of concern in different cultures and states. Thirty-five chapters address embryo definition, potential killing and the beginning of human life, in addition to matters of human dignity, patenting, commercialisation, and potential alternatives for the future, such as induced pluripotent (reprogrammed) stern cells. All arguments art compiled in a synopsis, and compromise solutions, e.g. for the definition of the beginning of personhood and for assigning dignity to embryos, art suggested. Until recently, the major application of hESC was thought to be transplantation of cells derived from hESC for therapeutic use. We discuss here that the most likely immediate uses will rather be in vitro test systems and disease models. Major and minor pharmaceutical companies have entered this field, and the European Union is sponsoring academic research into hESC-based innovative test systems. This development is supported by new testing strategies in Europe and the USA focussing oil human cell-based in vitro systems for safety evaluations, and shifting the focus of toxicology away from classical animal experiments towards a more mechanistic understanding. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1285900
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stem cell ethics, in vitro toxicology, human embryonic stem cells, iPs, cells
- in
- ALTEX Alternatives To Animal Experimentation
- volume
- 25
- issue
- 3
- pages
- 163 - 190
- publisher
- Spektrum Akad Verlag
- external identifiers
-
- wos:000259734300003
- scopus:58949087263
- ISSN
- 0946-7785
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- a725d28b-9ef7-4993-9009-aeb2162f6c50 (old id 1285900)
- alternative location
- http://www.altex.ch/de/index.html?id=49&iid=101&aid=3
- date added to LUP
- 2016-04-01 12:20:29
- date last changed
- 2022-01-27 02:18:48
@article{a725d28b-9ef7-4993-9009-aeb2162f6c50,
abstract = {{Human embryonic stern cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In all ongoing ethical debate opinions of different groups are based oil varying sets of religious, historical, cultural and scientific arguments as well as oil widely differing levels of general information. We here give all overview of the biological background for non-specialists, and address all issues of the current stern cell debate that are of concern in different cultures and states. Thirty-five chapters address embryo definition, potential killing and the beginning of human life, in addition to matters of human dignity, patenting, commercialisation, and potential alternatives for the future, such as induced pluripotent (reprogrammed) stern cells. All arguments art compiled in a synopsis, and compromise solutions, e.g. for the definition of the beginning of personhood and for assigning dignity to embryos, art suggested. Until recently, the major application of hESC was thought to be transplantation of cells derived from hESC for therapeutic use. We discuss here that the most likely immediate uses will rather be in vitro test systems and disease models. Major and minor pharmaceutical companies have entered this field, and the European Union is sponsoring academic research into hESC-based innovative test systems. This development is supported by new testing strategies in Europe and the USA focussing oil human cell-based in vitro systems for safety evaluations, and shifting the focus of toxicology away from classical animal experiments towards a more mechanistic understanding.}},
author = {{Leist, Marcel and Bremer, Susanne and Brundin, Patrik and Hescheler, Juergen and Kirkeby, Agnete and Krause, Karl-Heinz and Poerzgen, Peter and Puceat, Michel and Schmidt, Mathias and Schrattenholz, Andre and Zak, Naomi B. and Hentze, Hannes}},
issn = {{0946-7785}},
keywords = {{stem cell ethics; in vitro toxicology; human embryonic stem cells; iPs; cells}},
language = {{eng}},
number = {{3}},
pages = {{163--190}},
publisher = {{Spektrum Akad Verlag}},
series = {{ALTEX Alternatives To Animal Experimentation}},
title = {{The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy}},
url = {{http://www.altex.ch/de/index.html?id=49&iid=101&aid=3}},
volume = {{25}},
year = {{2008}},
}