Advanced

Lp-PLA(2) activity and mass are associated with increased incidence of ischemic stroke - A population-based cohort study from Malmo, Sweden

Persson, Margaretha LU ; Berglund, Göran LU ; Nelson, Jeanenne J. and Hedblad, Bo LU (2008) In Atherosclerosis 200(1). p.191-198
Abstract
Background: Data regarding the association between lipoprotein-associated phospholipase A2 (Lp-PLA(2)) level and incidence of cardiovascular (CV) events are conflicting. This prospective urban population-based study explored the relationship between baseline Lp-PLA(2) activity and mass, respectively, levels and incidence of first coronary heart disease (CHD) and ischemic stroke, respectively. Methods: Lp-PLA(2) activity and mass were assessed in 5393 (60% women) subjects who participated in the Malmo Diet and Cancer Study cardiovascular program during 1991-1994. Results: In all 347 subjects had an event (195 CHD and 152 ischemic strokes) during the follow-up period (mean 10.6 +/- 1.7 years). In an age-, sex- and CV risk factors-adjusted... (More)
Background: Data regarding the association between lipoprotein-associated phospholipase A2 (Lp-PLA(2)) level and incidence of cardiovascular (CV) events are conflicting. This prospective urban population-based study explored the relationship between baseline Lp-PLA(2) activity and mass, respectively, levels and incidence of first coronary heart disease (CHD) and ischemic stroke, respectively. Methods: Lp-PLA(2) activity and mass were assessed in 5393 (60% women) subjects who participated in the Malmo Diet and Cancer Study cardiovascular program during 1991-1994. Results: In all 347 subjects had an event (195 CHD and 152 ischemic strokes) during the follow-up period (mean 10.6 +/- 1.7 years). In an age-, sex- and CV risk factors-adjusted Cox regression analysis, comparing top to bottom tertile of Lp-PLA(2) activity, the relative risk [RR; 95% confidence interval (CI)] for incident CHD and ischemic stroke events were 1.48; 0.92-2.37 and RR: 1.94; 1.15-3.26, respectively. The corresponding figures for Lp-PLA(2) mass were 0.95; 0.65-1.40 and RR: 1.92; 1.20-3.10. Conclusion: Elevated levels of Lp-PLA(2) activity and mass, respectively, were in this study, independently of established risk factors related to the incidence of ischemic stroke but after adjustment for lipids not significant related to incident CHD. (C) 2007 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiovascular risk factors, Lp-PLA(2), inflammation, myocardial infarction, epidemiology
in
Atherosclerosis
volume
200
issue
1
pages
8 pages
publisher
Elsevier
external identifiers
  • wos:000259549800025
  • pmid:18201705
  • scopus:49949084572
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2007.12.001
language
English
LU publication?
yes
id
e384d047-9504-4e47-8a40-8c9a95d0a5d9 (old id 1286827)
date added to LUP
2009-01-29 10:50:23
date last changed
2017-07-23 03:42:18
@article{e384d047-9504-4e47-8a40-8c9a95d0a5d9,
  abstract     = {Background: Data regarding the association between lipoprotein-associated phospholipase A2 (Lp-PLA(2)) level and incidence of cardiovascular (CV) events are conflicting. This prospective urban population-based study explored the relationship between baseline Lp-PLA(2) activity and mass, respectively, levels and incidence of first coronary heart disease (CHD) and ischemic stroke, respectively. Methods: Lp-PLA(2) activity and mass were assessed in 5393 (60% women) subjects who participated in the Malmo Diet and Cancer Study cardiovascular program during 1991-1994. Results: In all 347 subjects had an event (195 CHD and 152 ischemic strokes) during the follow-up period (mean 10.6 +/- 1.7 years). In an age-, sex- and CV risk factors-adjusted Cox regression analysis, comparing top to bottom tertile of Lp-PLA(2) activity, the relative risk [RR; 95% confidence interval (CI)] for incident CHD and ischemic stroke events were 1.48; 0.92-2.37 and RR: 1.94; 1.15-3.26, respectively. The corresponding figures for Lp-PLA(2) mass were 0.95; 0.65-1.40 and RR: 1.92; 1.20-3.10. Conclusion: Elevated levels of Lp-PLA(2) activity and mass, respectively, were in this study, independently of established risk factors related to the incidence of ischemic stroke but after adjustment for lipids not significant related to incident CHD. (C) 2007 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Persson, Margaretha and Berglund, Göran and Nelson, Jeanenne J. and Hedblad, Bo},
  issn         = {1879-1484},
  keyword      = {cardiovascular risk factors,Lp-PLA(2),inflammation,myocardial infarction,epidemiology},
  language     = {eng},
  number       = {1},
  pages        = {191--198},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Lp-PLA(2) activity and mass are associated with increased incidence of ischemic stroke - A population-based cohort study from Malmo, Sweden},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2007.12.001},
  volume       = {200},
  year         = {2008},
}