The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer
Brennan, Donal ; Ek, Sara LU
; Doyle, Emma
; Drew, Thomas
; Foley, Michael
; Flannelly, Grainne
; O´Conner, Darren P
; Gallagher, William M
; Kilpinen, Sami
and Kallioniemi, Olli-Pekka
, et al.
(2009)
In European Journal of Cancer
45(8).
p.1510-1517
- Abstract
- Abstract
Background:
Current prognostic molecular markers for epithelial ovarian cancer (EOC) are
insufficient. The aim of the current study was to investigate the role of Sox11 in EOC
Methods:
Using an in silico transcriptomic screen Sox11 was identified as a potential EOC
biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)
in 76 EOC cases, which were analyzed using automated algorithms to develop a
quantitative scoring model.
Results:
Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.
Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in
40% of... (More) - Abstract
Background:
Current prognostic molecular markers for epithelial ovarian cancer (EOC) are
insufficient. The aim of the current study was to investigate the role of Sox11 in EOC
Methods:
Using an in silico transcriptomic screen Sox11 was identified as a potential EOC
biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)
in 76 EOC cases, which were analyzed using automated algorithms to develop a
quantitative scoring model.
Results:
Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.
Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in
40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002).
Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS
after controlling for stage and grade.
Conclusions:
These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is
associated with a decreased RFS and a more aggressive phenotype. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1288110
- author
- Brennan, Donal
; Ek, Sara
LU
; Doyle, Emma
; Drew, Thomas
; Foley, Michael
; Flannelly, Grainne
; O´Conner, Darren P
; Gallagher, William M
; Kilpinen, Sami
and Kallioniemi, Olli-Pekka
, et al. (More)
- Brennan, Donal
; Ek, Sara
LU
; Doyle, Emma
; Drew, Thomas
; Foley, Michael
; Flannelly, Grainne
; O´Conner, Darren P
; Gallagher, William M
; Kilpinen, Sami
; Kallioniemi, Olli-Pekka
; Jirström, Karin
LU
; O'Herlihy, Colm
and Borrebaeck, Carl
LU
(Less)
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cancer
- volume
- 45
- issue
- 8
- pages
- 1510 - 1517
- publisher
- Elsevier
- external identifiers
-
- wos:000266503800029
- scopus:65249085042
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2009.01.028
- language
- English
- LU publication?
- yes
- id
- e4802f32-ffcc-4790-8ea2-663556f045ce (old id 1288110)
- date added to LUP
- 2016-04-01 12:37:00
- date last changed
- 2024-11-06 18:27:32
@article{e4802f32-ffcc-4790-8ea2-663556f045ce,
abstract = {{Abstract<br/><br>
Background:<br/><br>
Current prognostic molecular markers for epithelial ovarian cancer (EOC) are<br/><br>
insufficient. The aim of the current study was to investigate the role of Sox11 in EOC<br/><br>
Methods:<br/><br>
Using an in silico transcriptomic screen Sox11 was identified as a potential EOC<br/><br>
biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)<br/><br>
in 76 EOC cases, which were analyzed using automated algorithms to develop a<br/><br>
quantitative scoring model.<br/><br>
Results:<br/><br>
Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.<br/><br>
Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in<br/><br>
40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002).<br/><br>
Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS<br/><br>
after controlling for stage and grade.<br/><br>
Conclusions:<br/><br>
These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is<br/><br>
associated with a decreased RFS and a more aggressive phenotype.}},
author = {{Brennan, Donal and Ek, Sara and Doyle, Emma and Drew, Thomas and Foley, Michael and Flannelly, Grainne and O´Conner, Darren P and Gallagher, William M and Kilpinen, Sami and Kallioniemi, Olli-Pekka and Jirström, Karin and O'Herlihy, Colm and Borrebaeck, Carl}},
issn = {{1879-0852}},
language = {{eng}},
number = {{8}},
pages = {{1510--1517}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer}},
url = {{http://dx.doi.org/10.1016/j.ejca.2009.01.028}},
doi = {{10.1016/j.ejca.2009.01.028}},
volume = {{45}},
year = {{2009}},
}