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The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer

Brennan, Donal; Ek, Sara LU ; Doyle, Emma; Drew, Thomas; Foley, Michael; Flannelly, Grainne; O´Conner, Darren P; Gallagher, William M; Kilpinen, Sami and Kallioniemi, Olli-Pekka, et al. (2009) In European Journal of Cancer 45(8). p.1510-1517
Abstract
Abstract

Background:

Current prognostic molecular markers for epithelial ovarian cancer (EOC) are

insufficient. The aim of the current study was to investigate the role of Sox11 in EOC

Methods:

Using an in silico transcriptomic screen Sox11 was identified as a potential EOC

biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)

in 76 EOC cases, which were analyzed using automated algorithms to develop a

quantitative scoring model.

Results:

Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.

Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in

40% of... (More)
Abstract

Background:

Current prognostic molecular markers for epithelial ovarian cancer (EOC) are

insufficient. The aim of the current study was to investigate the role of Sox11 in EOC

Methods:

Using an in silico transcriptomic screen Sox11 was identified as a potential EOC

biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)

in 76 EOC cases, which were analyzed using automated algorithms to develop a

quantitative scoring model.

Results:

Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.

Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in

40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002).

Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS

after controlling for stage and grade.

Conclusions:

These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is

associated with a decreased RFS and a more aggressive phenotype. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer
volume
45
issue
8
pages
1510 - 1517
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000266503800029
  • scopus:65249085042
ISSN
1879-0852
DOI
10.1016/j.ejca.2009.01.028
project
CREATE Health
language
English
LU publication?
yes
id
e4802f32-ffcc-4790-8ea2-663556f045ce (old id 1288110)
date added to LUP
2009-01-28 14:23:26
date last changed
2017-12-10 03:56:11
@article{e4802f32-ffcc-4790-8ea2-663556f045ce,
  abstract     = {Abstract<br/><br>
Background:<br/><br>
Current prognostic molecular markers for epithelial ovarian cancer (EOC) are<br/><br>
insufficient. The aim of the current study was to investigate the role of Sox11 in EOC<br/><br>
Methods:<br/><br>
Using an in silico transcriptomic screen Sox11 was identified as a potential EOC<br/><br>
biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC)<br/><br>
in 76 EOC cases, which were analyzed using automated algorithms to develop a<br/><br>
quantitative scoring model.<br/><br>
Results:<br/><br>
Sox11 mRNA expression was up-regulated in EOC compared to normal tissues.<br/><br>
Automated analysis of Sox11 in the EOC cohort revealed high expression of Sox11, in<br/><br>
40% of tumours, who had an improved recurrence free survival (RFS) (p= 0.002).<br/><br>
Multivariate analysis confirmed Sox11 was an independent predictor of improved RFS<br/><br>
after controlling for stage and grade.<br/><br>
Conclusions:<br/><br>
These data suggest that Sox11 is a new prognostic marker in EOC. Loss of SOX 11 is<br/><br>
associated with a decreased RFS and a more aggressive phenotype.},
  author       = {Brennan, Donal and Ek, Sara and Doyle, Emma and Drew, Thomas and Foley, Michael and Flannelly, Grainne and O´Conner, Darren P and Gallagher, William M and Kilpinen, Sami and Kallioniemi, Olli-Pekka and Jirström, Karin and O'Herlihy, Colm and Borrebaeck, Carl},
  issn         = {1879-0852},
  language     = {eng},
  number       = {8},
  pages        = {1510--1517},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer},
  url          = {http://dx.doi.org/10.1016/j.ejca.2009.01.028},
  volume       = {45},
  year         = {2009},
}