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Cerebrovascular endothelin receptor upregulation in cerebral ischemia.

Edvinsson, Lars LU (2009) In Current Vascular Pharmacology 7(1). p.26-33
Abstract
Stroke is a serious neurological disease and the third leading cause of death in the western world. In roughly 15 % of the cases, the cause is due to an intracranial haemorrhage, and the remaining 85 % represent ischemic strokes. Ischemic stroke is caused by the occlusion of a cerebral artery either by an embolus or by local thrombosis. Several studies have shown an involvement of the endothelin system in ischemic stroke. This review aims to examine the alterations of vascular endothelin receptor expression in ischemic stroke. Furthermore, studies of the intracellular signalling pathways leading to the enhanced expression of vascular endothelin receptors show that both protein kinase C (PKC) and mitogen activating protein kinase (MAPK)... (More)
Stroke is a serious neurological disease and the third leading cause of death in the western world. In roughly 15 % of the cases, the cause is due to an intracranial haemorrhage, and the remaining 85 % represent ischemic strokes. Ischemic stroke is caused by the occlusion of a cerebral artery either by an embolus or by local thrombosis. Several studies have shown an involvement of the endothelin system in ischemic stroke. This review aims to examine the alterations of vascular endothelin receptor expression in ischemic stroke. Furthermore, studies of the intracellular signalling pathways leading to the enhanced expression of vascular endothelin receptors show that both protein kinase C (PKC) and mitogen activating protein kinase (MAPK) play important roles. The results from this work provide new perspectives on the pathophysiology of ischemic stroke, and give a possible explanation to the beneficial effects of treatment with PKC and MAPK inhibitors to limit the infarct volume. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Vascular Pharmacology
volume
7
issue
1
pages
26 - 33
publisher
Bentham Science Publishers
external identifiers
  • wos:000263970400004
  • pmid:19149637
  • scopus:61549131265
ISSN
1570-1611
language
English
LU publication?
yes
id
fb8250dd-7735-4120-bf80-bd42a0709e2c (old id 1289653)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19149637?dopt=Abstract
date added to LUP
2009-02-03 11:27:47
date last changed
2017-11-19 04:16:51
@article{fb8250dd-7735-4120-bf80-bd42a0709e2c,
  abstract     = {Stroke is a serious neurological disease and the third leading cause of death in the western world. In roughly 15 % of the cases, the cause is due to an intracranial haemorrhage, and the remaining 85 % represent ischemic strokes. Ischemic stroke is caused by the occlusion of a cerebral artery either by an embolus or by local thrombosis. Several studies have shown an involvement of the endothelin system in ischemic stroke. This review aims to examine the alterations of vascular endothelin receptor expression in ischemic stroke. Furthermore, studies of the intracellular signalling pathways leading to the enhanced expression of vascular endothelin receptors show that both protein kinase C (PKC) and mitogen activating protein kinase (MAPK) play important roles. The results from this work provide new perspectives on the pathophysiology of ischemic stroke, and give a possible explanation to the beneficial effects of treatment with PKC and MAPK inhibitors to limit the infarct volume.},
  author       = {Edvinsson, Lars},
  issn         = {1570-1611},
  language     = {eng},
  number       = {1},
  pages        = {26--33},
  publisher    = {Bentham Science Publishers},
  series       = {Current Vascular Pharmacology},
  title        = {Cerebrovascular endothelin receptor upregulation in cerebral ischemia.},
  volume       = {7},
  year         = {2009},
}