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Survival after stroke - The impact of CHADS(2) score and atrial fibrillation.

Henriksson, Karin LU ; Farahmand, Bahman; Johansson, Saga; Asberg, Signild; Terént, Andreas and Edvardsson, Nils (2010) In International Journal of Cardiology 141. p.18-23
Abstract
OBJECTIVE: This study examined all-cause mortality in stroke patients with and without documented atrial fibrillation (AF), and the impact of CHADS(2) score. DESIGN: A cohort of 105,074 patients, 31,821 (30.3%) with and 73,253 (69.7%) without documented AF, was studied. These patients were registered in the Swedish Stroke Registry during the years 2001-2005. Mortality data were retrieved from the Swedish Cause of Death Register. CHADS(2) score prior to stroke were assessed using the Swedish National Discharge Register. RESULTS: The age and sex adjusted relative risk (RR) of death was 1.46 (1.43-1.49) for AF vs non-AF patients. High age (>/=75 years) tripled the risk of death and was the single most important predictor, followed by... (More)
OBJECTIVE: This study examined all-cause mortality in stroke patients with and without documented atrial fibrillation (AF), and the impact of CHADS(2) score. DESIGN: A cohort of 105,074 patients, 31,821 (30.3%) with and 73,253 (69.7%) without documented AF, was studied. These patients were registered in the Swedish Stroke Registry during the years 2001-2005. Mortality data were retrieved from the Swedish Cause of Death Register. CHADS(2) score prior to stroke were assessed using the Swedish National Discharge Register. RESULTS: The age and sex adjusted relative risk (RR) of death was 1.46 (1.43-1.49) for AF vs non-AF patients. High age (>/=75 years) tripled the risk of death and was the single most important predictor, followed by congestive heart failure, previous stroke and diabetes. Less than half of the AF patients with a CHADS(2) score of 1-6 survived more than 5 years, whereas AF patients with a CHADS(2) score of 0 had a 73% chance of survival. In patients with AF, the relative risk of death was 6.05 (CI: 2.26-6.95); in subjects with the highest vs the lowest CHADS(2) score; the corresponding RR for non-AF patients was 7.93 (CI: 7.01-8.97). CONCLUSIONS: The CHADS(2) score seems to have an impact on all-cause mortality after stroke. The CHADS(2) score can give valuable insight for other outcome variables apart from having had an ischemic stroke and can be applied to patients with different risk factor profiles, e.g. with a previous known cardiovascular disease but without known AF. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cardiology
volume
141
pages
18 - 23
publisher
Elsevier
external identifiers
  • wos:000277411500004
  • pmid:19144430
  • scopus:77951667741
ISSN
0167-5273
DOI
10.1016/j.ijcard.2008.11.122
language
English
LU publication?
yes
id
1ce56d73-8190-4151-9f41-ffd4b646a67a (old id 1289693)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19144430?dopt=Abstract
date added to LUP
2009-02-04 10:49:20
date last changed
2018-05-29 10:43:10
@article{1ce56d73-8190-4151-9f41-ffd4b646a67a,
  abstract     = {OBJECTIVE: This study examined all-cause mortality in stroke patients with and without documented atrial fibrillation (AF), and the impact of CHADS(2) score. DESIGN: A cohort of 105,074 patients, 31,821 (30.3%) with and 73,253 (69.7%) without documented AF, was studied. These patients were registered in the Swedish Stroke Registry during the years 2001-2005. Mortality data were retrieved from the Swedish Cause of Death Register. CHADS(2) score prior to stroke were assessed using the Swedish National Discharge Register. RESULTS: The age and sex adjusted relative risk (RR) of death was 1.46 (1.43-1.49) for AF vs non-AF patients. High age (>/=75 years) tripled the risk of death and was the single most important predictor, followed by congestive heart failure, previous stroke and diabetes. Less than half of the AF patients with a CHADS(2) score of 1-6 survived more than 5 years, whereas AF patients with a CHADS(2) score of 0 had a 73% chance of survival. In patients with AF, the relative risk of death was 6.05 (CI: 2.26-6.95); in subjects with the highest vs the lowest CHADS(2) score; the corresponding RR for non-AF patients was 7.93 (CI: 7.01-8.97). CONCLUSIONS: The CHADS(2) score seems to have an impact on all-cause mortality after stroke. The CHADS(2) score can give valuable insight for other outcome variables apart from having had an ischemic stroke and can be applied to patients with different risk factor profiles, e.g. with a previous known cardiovascular disease but without known AF.},
  author       = {Henriksson, Karin and Farahmand, Bahman and Johansson, Saga and Asberg, Signild and Terént, Andreas and Edvardsson, Nils},
  issn         = {0167-5273},
  language     = {eng},
  pages        = {18--23},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Survival after stroke - The impact of CHADS(2) score and atrial fibrillation.},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2008.11.122},
  volume       = {141},
  year         = {2010},
}