Elevated infection parameters and infection symptoms predict an acute coronary event.
Pesonen, Erkki LU ; Andsberg, Eva ; Grubb, Anders LU
; Rautelin, Hilpi
; Meri, Seppo
; Persson, Kenneth
LU
; Puolakkainen, Mirja
; Sarna, Seppo
and Öhlin, Hans
LU
(2008)
In Therapeutic Advances in Cardiovascular Disease
2(6).
p.419-424
- Abstract
- BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p<0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p<0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs... (More)
- BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p<0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p<0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs 1.45 and 4.29 vs 3.73) than in controls without fatigue but only HSV titers were statistically significantly higher (3.47 vs 3.96, p = 0.02). Even CRP and amyloid A concentrations (3.49 vs 2.08, p<0.0001 and 5.70 vs 3.77 mg/l, p = 0.003, respectively) as well as C4 (0.40 vs 0.44, p = 0.02) were higher in controls with fatigue. CONCLUSIONS: Odds ratios for a coronary event in a logistic regression model were 4.79 for fatigue and 2.72 for EV antibody levels in their fourth quartile. A linear-by-linear association test showed increasing number of single symptoms with higher EV titer quartiles (p = 0.004). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1289978
- author
- Pesonen, Erkki
LU
; Andsberg, Eva
; Grubb, Anders
LU
; Rautelin, Hilpi
; Meri, Seppo
; Persson, Kenneth
LU
; Puolakkainen, Mirja
; Sarna, Seppo
and Öhlin, Hans
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Therapeutic Advances in Cardiovascular Disease
- volume
- 2
- issue
- 6
- pages
- 419 - 424
- publisher
- SAGE Publications
- external identifiers
-
- pmid:19124438
- scopus:68749106221
- pmid:19124438
- ISSN
- 1753-9447
- DOI
- 10.1177/1753944708098695
- language
- English
- LU publication?
- yes
- id
- b3228826-7d1a-40cc-9415-3e8f1ab4637c (old id 1289978)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19124438?dopt=Abstract
- http://tak.sagepub.com/content/2/6/419
- date added to LUP
- 2016-04-04 09:30:28
- date last changed
- 2023-01-21 03:29:39
@article{b3228826-7d1a-40cc-9415-3e8f1ab4637c,
abstract = {{BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p<0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p<0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs 1.45 and 4.29 vs 3.73) than in controls without fatigue but only HSV titers were statistically significantly higher (3.47 vs 3.96, p = 0.02). Even CRP and amyloid A concentrations (3.49 vs 2.08, p<0.0001 and 5.70 vs 3.77 mg/l, p = 0.003, respectively) as well as C4 (0.40 vs 0.44, p = 0.02) were higher in controls with fatigue. CONCLUSIONS: Odds ratios for a coronary event in a logistic regression model were 4.79 for fatigue and 2.72 for EV antibody levels in their fourth quartile. A linear-by-linear association test showed increasing number of single symptoms with higher EV titer quartiles (p = 0.004).}},
author = {{Pesonen, Erkki and Andsberg, Eva and Grubb, Anders and Rautelin, Hilpi and Meri, Seppo and Persson, Kenneth and Puolakkainen, Mirja and Sarna, Seppo and Öhlin, Hans}},
issn = {{1753-9447}},
language = {{eng}},
number = {{6}},
pages = {{419--424}},
publisher = {{SAGE Publications}},
series = {{Therapeutic Advances in Cardiovascular Disease}},
title = {{Elevated infection parameters and infection symptoms predict an acute coronary event.}},
url = {{http://dx.doi.org/10.1177/1753944708098695}},
doi = {{10.1177/1753944708098695}},
volume = {{2}},
year = {{2008}},
}