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Elevated infection parameters and infection symptoms predict an acute coronary event.

Pesonen, Erkki LU ; Andsberg, Eva; Grubb, Anders LU ; Rautelin, Hilpi; Meri, Seppo; Persson, Kenneth LU ; Puolakkainen, Mirja; Sarna, Seppo and Öhlin, Hans LU (2008) In Therapeutic Advances in Cardiovascular Disease 2(6). p.419-424
Abstract
BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p<0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p<0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs... (More)
BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p<0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p<0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs 1.45 and 4.29 vs 3.73) than in controls without fatigue but only HSV titers were statistically significantly higher (3.47 vs 3.96, p = 0.02). Even CRP and amyloid A concentrations (3.49 vs 2.08, p<0.0001 and 5.70 vs 3.77 mg/l, p = 0.003, respectively) as well as C4 (0.40 vs 0.44, p = 0.02) were higher in controls with fatigue. CONCLUSIONS: Odds ratios for a coronary event in a logistic regression model were 4.79 for fatigue and 2.72 for EV antibody levels in their fourth quartile. A linear-by-linear association test showed increasing number of single symptoms with higher EV titer quartiles (p = 0.004). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Therapeutic Advances in Cardiovascular Disease
volume
2
issue
6
pages
419 - 424
publisher
SAGE Publications
external identifiers
  • PMID:19124438
  • Scopus:68749106221
ISSN
1753-9447
DOI
10.1177/1753944708098695
language
English
LU publication?
yes
id
b3228826-7d1a-40cc-9415-3e8f1ab4637c (old id 1289978)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19124438?dopt=Abstract
http://tak.sagepub.com/content/2/6/419
date added to LUP
2009-02-03 10:39:11
date last changed
2017-01-01 07:50:08
@article{b3228826-7d1a-40cc-9415-3e8f1ab4637c,
  abstract     = {BACKGROUND: The etiology and significance of flu-like symptoms often appearing before myocardial infarction should be clarified. METHODS: In a case-control study of 323 matched controls and a random sample of 110 out of 351 cases the presence of infection symptoms during the preceding four weeks before admission were asked and blood samples taken. RESULTS: Enterovirus (EV), herpes simplex virus (HSV), and Chlamydia pneumoniae IgA titers were significantly higher in cases than in controls (p&lt;0.001, 0.008 and 0.046, respectively). Flu-like symptoms appeared significantly more often in patients than in controls the most common one being fatigue (p&lt;0.001). In controls with fatigue, EV and HSV titers showed a trend to be higher (1.50 vs 1.45 and 4.29 vs 3.73) than in controls without fatigue but only HSV titers were statistically significantly higher (3.47 vs 3.96, p = 0.02). Even CRP and amyloid A concentrations (3.49 vs 2.08, p&lt;0.0001 and 5.70 vs 3.77 mg/l, p = 0.003, respectively) as well as C4 (0.40 vs 0.44, p = 0.02) were higher in controls with fatigue. CONCLUSIONS: Odds ratios for a coronary event in a logistic regression model were 4.79 for fatigue and 2.72 for EV antibody levels in their fourth quartile. A linear-by-linear association test showed increasing number of single symptoms with higher EV titer quartiles (p = 0.004).},
  author       = {Pesonen, Erkki and Andsberg, Eva and Grubb, Anders and Rautelin, Hilpi and Meri, Seppo and Persson, Kenneth and Puolakkainen, Mirja and Sarna, Seppo and Öhlin, Hans},
  issn         = {1753-9447},
  language     = {eng},
  number       = {6},
  pages        = {419--424},
  publisher    = {SAGE Publications},
  series       = {Therapeutic Advances in Cardiovascular Disease},
  title        = {Elevated infection parameters and infection symptoms predict an acute coronary event.},
  url          = {http://dx.doi.org/10.1177/1753944708098695},
  volume       = {2},
  year         = {2008},
}