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Synthesis and studies of N-vinylcaprolactam/N-vinylimidazole copolymers taht exhibit the ”proteinlike” behaviour in aquesous media

Lozinsky, Vladimir I; Simenel, Irina A; Kulakova, Valentina K; Kurskaya, Elena A; Babushkina, Tatyana A; Klimova, Tamara P; Burova, Tatyana V; Dubovik, Alexander S; Grinberg, Valerij Ya and Galaev, Igor LU , et al. (2003) In Macromolecules 36(19). p.7308-7323
Abstract
Proteinlike copolymers were first predicted by the computer-aided biomimetic design (Physica A 1998, 249, 253-261). These copolymers consist of comonomer units of differing hydrophilicity/hydrophobicity. Heterogeneous blockiness, characteristic for such copolymers, facilitates chain folding with the formation of specific spatial packing: a dense core consisting of hydrophobic units and a polar shell formed by hydrophilic units. This paper describes the synthesis of N-vinylcaprolactam/N-vinylimidazole copolymers via the redox-initiated radical copolymerization in the medium of 10% aqueous DMSO at the temperatures both below and above the phase separation threshold. The synthesized macromolecular products were separated into thermally... (More)
Proteinlike copolymers were first predicted by the computer-aided biomimetic design (Physica A 1998, 249, 253-261). These copolymers consist of comonomer units of differing hydrophilicity/hydrophobicity. Heterogeneous blockiness, characteristic for such copolymers, facilitates chain folding with the formation of specific spatial packing: a dense core consisting of hydrophobic units and a polar shell formed by hydrophilic units. This paper describes the synthesis of N-vinylcaprolactam/N-vinylimidazole copolymers via the redox-initiated radical copolymerization in the medium of 10% aqueous DMSO at the temperatures both below and above the phase separation threshold. The synthesized macromolecular products were separated into thermally precipitating and nonprecipitating fractions. Their molecular weight characteristics were evaluated using size-exclusion chromatography; their comonomer composition was determined from 1H NMR spectra of copolymers dissolved in DMSO-d6. The temperature-dependent behavior of copolymer macromolecules in water was investigated by thermonephelometry, high-sensitivity differential scanning calorimetry, and 1H NMR spectroscopy of the copolymers dissolved in D2O. It was shown that thermally nonprecipitating copolymer fractions obtained at initial comonomer molar ratios of 85:15 and 90:10 can be identified as proteinlike copolymers. (Less)
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publication status
published
subject
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Macromolecules
volume
36
issue
19
pages
7308 - 7323
publisher
The American Chemical Society
external identifiers
  • wos:000185443600048
  • scopus:0141509037
ISSN
0024-9297
DOI
10.1021/ma034456n
language
English
LU publication?
yes
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a9be337e-c1fd-4cdd-ba08-84b03f245c03 (old id 129188)
date added to LUP
2007-07-02 13:26:31
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2018-05-29 11:55:58
@article{a9be337e-c1fd-4cdd-ba08-84b03f245c03,
  abstract     = {Proteinlike copolymers were first predicted by the computer-aided biomimetic design (Physica A 1998, 249, 253-261). These copolymers consist of comonomer units of differing hydrophilicity/hydrophobicity. Heterogeneous blockiness, characteristic for such copolymers, facilitates chain folding with the formation of specific spatial packing: a dense core consisting of hydrophobic units and a polar shell formed by hydrophilic units. This paper describes the synthesis of N-vinylcaprolactam/N-vinylimidazole copolymers via the redox-initiated radical copolymerization in the medium of 10% aqueous DMSO at the temperatures both below and above the phase separation threshold. The synthesized macromolecular products were separated into thermally precipitating and nonprecipitating fractions. Their molecular weight characteristics were evaluated using size-exclusion chromatography; their comonomer composition was determined from 1H NMR spectra of copolymers dissolved in DMSO-d6. The temperature-dependent behavior of copolymer macromolecules in water was investigated by thermonephelometry, high-sensitivity differential scanning calorimetry, and 1H NMR spectroscopy of the copolymers dissolved in D2O. It was shown that thermally nonprecipitating copolymer fractions obtained at initial comonomer molar ratios of 85:15 and 90:10 can be identified as proteinlike copolymers.},
  author       = {Lozinsky, Vladimir I and Simenel, Irina A and Kulakova, Valentina K and Kurskaya, Elena A and Babushkina, Tatyana A and Klimova, Tamara P and Burova, Tatyana V and Dubovik, Alexander S and Grinberg, Valerij Ya and Galaev, Igor and Mattiasson, Bo and Khokhlov, Alexei R},
  issn         = {0024-9297},
  language     = {eng},
  number       = {19},
  pages        = {7308--7323},
  publisher    = {The American Chemical Society},
  series       = {Macromolecules},
  title        = {Synthesis and studies of N-vinylcaprolactam/N-vinylimidazole copolymers taht exhibit the ”proteinlike” behaviour in aquesous media},
  url          = {http://dx.doi.org/10.1021/ma034456n},
  volume       = {36},
  year         = {2003},
}