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Atomic Force Microscopy Analysis and Confocal Raman Microimaging of Coated Pellets

Ringqvist, Ann LU ; Taylor, Lynne S; Ekelund, Katarina; Ragnarsson, G; Engström, S and Axelsson, Anders LU (2003) In International Journal of Pharmaceutics 267(1-2). p.35-47
Abstract
Polymer-coated pellets with different coating thicknesses have been studied regarding coating morphology and drug release properties with atomic force microscopy (AFM) and confocal Raman microscopy. The results were compared with those from scanning electron microscopy (SEM) and drug release profiles, which have been measured previously for these systems and found to vary depending on coating thickness. Results from AFM studies indicated that these pellets differ in the amount of crystalline material on the surface of the coating. The amount was found to be highest on the pellet with the thinnest coating. Confocal Raman microscopy studies confirmed that the active component (remoxipride hydrochloride monohydrate) is present at or close to... (More)
Polymer-coated pellets with different coating thicknesses have been studied regarding coating morphology and drug release properties with atomic force microscopy (AFM) and confocal Raman microscopy. The results were compared with those from scanning electron microscopy (SEM) and drug release profiles, which have been measured previously for these systems and found to vary depending on coating thickness. Results from AFM studies indicated that these pellets differ in the amount of crystalline material on the surface of the coating. The amount was found to be highest on the pellet with the thinnest coating. Confocal Raman microscopy studies confirmed that the active component (remoxipride hydrochloride monohydrate) is present at or close to the surface and that the amount is higher for the thinnest coating. AFM studies in aqueous media showed that the crystalline material on the surface was almost instantaneously dissolved and released into the liquid. AFM has proven to be a powerful tool in the study of the surface of dry formulations and in the study of the controlled release mechanism of a pharmaceutical in a liquid cell. The method can be combined with Raman, giving the added possibility to identify the chemical composition in selected small areas of the coating surface. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Pharmaceutics
volume
267
issue
1-2
pages
35 - 47
publisher
Elsevier
external identifiers
  • wos:000186794600004
  • pmid:14602382
  • scopus:0242329805
ISSN
1873-3476
DOI
10.1016/j.ijpharm.2003.07.004
language
English
LU publication?
yes
id
04ecce87-616b-4db8-89d1-f4a4fb61068f (old id 129379)
date added to LUP
2007-06-25 15:38:31
date last changed
2017-01-01 04:52:48
@article{04ecce87-616b-4db8-89d1-f4a4fb61068f,
  abstract     = {Polymer-coated pellets with different coating thicknesses have been studied regarding coating morphology and drug release properties with atomic force microscopy (AFM) and confocal Raman microscopy. The results were compared with those from scanning electron microscopy (SEM) and drug release profiles, which have been measured previously for these systems and found to vary depending on coating thickness. Results from AFM studies indicated that these pellets differ in the amount of crystalline material on the surface of the coating. The amount was found to be highest on the pellet with the thinnest coating. Confocal Raman microscopy studies confirmed that the active component (remoxipride hydrochloride monohydrate) is present at or close to the surface and that the amount is higher for the thinnest coating. AFM studies in aqueous media showed that the crystalline material on the surface was almost instantaneously dissolved and released into the liquid. AFM has proven to be a powerful tool in the study of the surface of dry formulations and in the study of the controlled release mechanism of a pharmaceutical in a liquid cell. The method can be combined with Raman, giving the added possibility to identify the chemical composition in selected small areas of the coating surface.},
  author       = {Ringqvist, Ann and Taylor, Lynne S and Ekelund, Katarina and Ragnarsson, G and Engström, S and Axelsson, Anders},
  issn         = {1873-3476},
  language     = {eng},
  number       = {1-2},
  pages        = {35--47},
  publisher    = {Elsevier},
  series       = {International Journal of Pharmaceutics},
  title        = {Atomic Force Microscopy Analysis and Confocal Raman Microimaging of Coated Pellets},
  url          = {http://dx.doi.org/10.1016/j.ijpharm.2003.07.004},
  volume       = {267},
  year         = {2003},
}