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Functional imaging of the frontal lobes in organic dementia. Regional cerebral blood flow findings in normals, in patients with frontotemporal dementia and in patients with Alzheimer's disease, performing a word fluency test

Warkentin, Siegbert LU and Passant, Ulla LU (1997) In Dementia and Geriatric Cognitive Disorders 8(2). p.105-109
Abstract
Patterns of functional cortical activation were studied by means of regional cerebral blood flow measurements, performed during rest and during a word fluency task in normal subjects (n = 22), in patients with Alzheimer's disease (n = 17), and in patients with frontotemporal dementia (n = 15). Although all groups showed a significant activation of the Broca's area during word production, the activation of the dorsolateral prefrontal cortex was clearly subnormal in both dementia groups. The frontal dysfunction was not explained by number of words produced, illness duration, or age. Thus, the results demonstrate that the word fluency task is a sensitive measure of frontal lobe function, and its incorporation in imaging studies may facilitate... (More)
Patterns of functional cortical activation were studied by means of regional cerebral blood flow measurements, performed during rest and during a word fluency task in normal subjects (n = 22), in patients with Alzheimer's disease (n = 17), and in patients with frontotemporal dementia (n = 15). Although all groups showed a significant activation of the Broca's area during word production, the activation of the dorsolateral prefrontal cortex was clearly subnormal in both dementia groups. The frontal dysfunction was not explained by number of words produced, illness duration, or age. Thus, the results demonstrate that the word fluency task is a sensitive measure of frontal lobe function, and its incorporation in imaging studies may facilitate the detection of subtle functional impairment of the frontal lobes in organic dementia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
8
issue
2
pages
105 - 109
publisher
Karger
ISSN
1420-8008
DOI
10.1159/000106614
language
English
LU publication?
yes
id
68cb895a-23a2-44bb-b17b-de38a894e27f (old id 1296480)
date added to LUP
2009-07-31 13:54:54
date last changed
2016-04-15 19:48:36
@article{68cb895a-23a2-44bb-b17b-de38a894e27f,
  abstract     = {Patterns of functional cortical activation were studied by means of regional cerebral blood flow measurements, performed during rest and during a word fluency task in normal subjects (n = 22), in patients with Alzheimer's disease (n = 17), and in patients with frontotemporal dementia (n = 15). Although all groups showed a significant activation of the Broca's area during word production, the activation of the dorsolateral prefrontal cortex was clearly subnormal in both dementia groups. The frontal dysfunction was not explained by number of words produced, illness duration, or age. Thus, the results demonstrate that the word fluency task is a sensitive measure of frontal lobe function, and its incorporation in imaging studies may facilitate the detection of subtle functional impairment of the frontal lobes in organic dementia.},
  author       = {Warkentin, Siegbert and Passant, Ulla},
  issn         = {1420-8008},
  language     = {eng},
  number       = {2},
  pages        = {105--109},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Functional imaging of the frontal lobes in organic dementia. Regional cerebral blood flow findings in normals, in patients with frontotemporal dementia and in patients with Alzheimer's disease, performing a word fluency test},
  url          = {http://dx.doi.org/10.1159/000106614},
  volume       = {8},
  year         = {1997},
}