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What margins should be added to the clinical target volume in radiotherapy treatment planning for lung cancer?

Ekberg, Lars; Holmberg, Ola LU ; Wittgren, Lena LU ; Bjelkengren, Göran LU and Landberg, Torsten LU (1988) In Radiotherapy and Oncology 48(1). p.71-77
Abstract
BACKGROUND: The planning target volume in radiotherapy treatment planning takes into account both movements of the clinical target volume (CTV) and set-up deviations. MATERIALS AND METHODS: A group of patients who received radiotherapy for lung cancer were studied. In order to measure the CTV movements due to respiration and other internal organ motions, fluoroscopy was performed for 20 patients. To study the accuracy and reproducibility of patient and beam set-up, 553 electronic portal images from 20 patients were evaluated. Discrepancies between planned and actual field positions were measured and the systematic and random errors were identified. The combined effect of these geometrical variations was evaluated. RESULTS: The average CTV... (More)
BACKGROUND: The planning target volume in radiotherapy treatment planning takes into account both movements of the clinical target volume (CTV) and set-up deviations. MATERIALS AND METHODS: A group of patients who received radiotherapy for lung cancer were studied. In order to measure the CTV movements due to respiration and other internal organ motions, fluoroscopy was performed for 20 patients. To study the accuracy and reproducibility of patient and beam set-up, 553 electronic portal images from 20 patients were evaluated. Discrepancies between planned and actual field positions were measured and the systematic and random errors were identified. The combined effect of these geometrical variations was evaluated. RESULTS: The average CTV movement with quiet respiration was about 2.4 mm in the medio-lateral and dorso-ventral directions. Movement in the cranio-caudal direction was on average 3.9 mm with a range of 0-12 mm. The systematic set-up errors were on average 2.0 mm in the transversal plane and 3.0 mm in the cranio-caudal direction. The random errors can be described by their standard deviations of 3.2 and 2.6 mm. In this study, the combined effect of the two parameters (CTV movement and set-up deviations) varied between 7.5 and 10.3 mm in different anatomical directions. CONCLUSIONS: In our daily clinical routine, we use a margin of 11 mm in the transversal plane and 15 mm cranially and caudally, also taking into account other unquantified variations and uncertainties. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiotherapy and Oncology
volume
48
issue
1
pages
71 - 77
publisher
Elsevier
external identifiers
  • scopus:0031870905
ISSN
1879-0887
DOI
10.1016/S0167-8140(98)00046-2
language
English
LU publication?
yes
id
f90c94b3-1e35-4e4b-95e7-df190db340ea (old id 1296541)
date added to LUP
2009-07-31 11:52:01
date last changed
2017-07-30 03:39:46
@article{f90c94b3-1e35-4e4b-95e7-df190db340ea,
  abstract     = {BACKGROUND: The planning target volume in radiotherapy treatment planning takes into account both movements of the clinical target volume (CTV) and set-up deviations. MATERIALS AND METHODS: A group of patients who received radiotherapy for lung cancer were studied. In order to measure the CTV movements due to respiration and other internal organ motions, fluoroscopy was performed for 20 patients. To study the accuracy and reproducibility of patient and beam set-up, 553 electronic portal images from 20 patients were evaluated. Discrepancies between planned and actual field positions were measured and the systematic and random errors were identified. The combined effect of these geometrical variations was evaluated. RESULTS: The average CTV movement with quiet respiration was about 2.4 mm in the medio-lateral and dorso-ventral directions. Movement in the cranio-caudal direction was on average 3.9 mm with a range of 0-12 mm. The systematic set-up errors were on average 2.0 mm in the transversal plane and 3.0 mm in the cranio-caudal direction. The random errors can be described by their standard deviations of 3.2 and 2.6 mm. In this study, the combined effect of the two parameters (CTV movement and set-up deviations) varied between 7.5 and 10.3 mm in different anatomical directions. CONCLUSIONS: In our daily clinical routine, we use a margin of 11 mm in the transversal plane and 15 mm cranially and caudally, also taking into account other unquantified variations and uncertainties.},
  author       = {Ekberg, Lars and Holmberg, Ola and Wittgren, Lena and Bjelkengren, Göran and Landberg, Torsten},
  issn         = {1879-0887},
  language     = {eng},
  number       = {1},
  pages        = {71--77},
  publisher    = {Elsevier},
  series       = {Radiotherapy and Oncology},
  title        = {What margins should be added to the clinical target volume in radiotherapy treatment planning for lung cancer?},
  url          = {http://dx.doi.org/10.1016/S0167-8140(98)00046-2},
  volume       = {48},
  year         = {1988},
}