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Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements

Bäck, Sven LU ; Medin, Joakim LU ; Magnusson, Peter; Olsson, P; Grusell, E and Olsson, Lars E LU (1999) In Physics in Medicine and Biology 44(8). p.1983-1996
Abstract
Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from... (More)
Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from that obtained using photon beams. However, on normalization at the entrance, the relative 1/T1 at the Bragg peak was 15-20% lower than the corresponding ionization chamber data for the monoenergetic proton beam. Better agreement was found for the modulated beam, but with significant differences close to the distal edge of the 1/T1 distribution. The change in sensitivity with depth was explained by means of a linear energy transfer dependence. This property was further studied using Monte Carlo methods. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
44
issue
8
pages
1983 - 1996
publisher
IOP Publishing
external identifiers
  • scopus:0344980330
ISSN
1361-6560
DOI
10.1088/0031-9155/44/8/310
language
English
LU publication?
yes
id
4cba1e71-af7d-49b2-8fdb-a9b4eaf77c82 (old id 1296617)
date added to LUP
2009-07-31 13:20:23
date last changed
2017-07-23 03:47:30
@article{4cba1e71-af7d-49b2-8fdb-a9b4eaf77c82,
  abstract     = {Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from that obtained using photon beams. However, on normalization at the entrance, the relative 1/T1 at the Bragg peak was 15-20% lower than the corresponding ionization chamber data for the monoenergetic proton beam. Better agreement was found for the modulated beam, but with significant differences close to the distal edge of the 1/T1 distribution. The change in sensitivity with depth was explained by means of a linear energy transfer dependence. This property was further studied using Monte Carlo methods.},
  author       = {Bäck, Sven and Medin, Joakim and Magnusson, Peter and Olsson, P and Grusell, E and Olsson, Lars E},
  issn         = {1361-6560},
  language     = {eng},
  number       = {8},
  pages        = {1983--1996},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements},
  url          = {http://dx.doi.org/10.1088/0031-9155/44/8/310},
  volume       = {44},
  year         = {1999},
}