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GABA transporters (GAT-1) in Alzheimer's disease

Nägga, Katarina LU ; Bogdanovic, N and Marcusson, J (1999) In Journal of Neural Transmission 106(11-12). p.1141-1149
Abstract
The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [3H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neural Transmission
volume
106
issue
11-12
pages
1141 - 1149
publisher
Springer
external identifiers
  • scopus:0343048399
ISSN
0300-9564
DOI
10.1007/s007020050230
language
English
LU publication?
no
id
889dc21f-4a8a-4d55-b5a8-7c493f14110f (old id 1296707)
date added to LUP
2009-07-30 14:56:21
date last changed
2017-09-10 04:38:09
@article{889dc21f-4a8a-4d55-b5a8-7c493f14110f,
  abstract     = {The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [3H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.},
  author       = {Nägga, Katarina and Bogdanovic, N and Marcusson, J},
  issn         = {0300-9564},
  language     = {eng},
  number       = {11-12},
  pages        = {1141--1149},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {GABA transporters (GAT-1) in Alzheimer's disease},
  url          = {http://dx.doi.org/10.1007/s007020050230},
  volume       = {106},
  year         = {1999},
}