GABA transporters (GAT-1) in Alzheimer's disease
(1999) In Journal of Neural Transmission 106(11-12). p.1141-1149- Abstract
- The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [3H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1296707
- author
- Nägga, Katarina LU ; Bogdanovic, N and Marcusson, J
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neural Transmission
- volume
- 106
- issue
- 11-12
- pages
- 1141 - 1149
- publisher
- Springer
- external identifiers
-
- scopus:0343048399
- ISSN
- 0300-9564
- DOI
- 10.1007/s007020050230
- language
- English
- LU publication?
- no
- id
- 889dc21f-4a8a-4d55-b5a8-7c493f14110f (old id 1296707)
- date added to LUP
- 2016-04-01 16:50:28
- date last changed
- 2022-01-28 22:33:57
@article{889dc21f-4a8a-4d55-b5a8-7c493f14110f, abstract = {{The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [3H]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.}}, author = {{Nägga, Katarina and Bogdanovic, N and Marcusson, J}}, issn = {{0300-9564}}, language = {{eng}}, number = {{11-12}}, pages = {{1141--1149}}, publisher = {{Springer}}, series = {{Journal of Neural Transmission}}, title = {{GABA transporters (GAT-1) in Alzheimer's disease}}, url = {{http://dx.doi.org/10.1007/s007020050230}}, doi = {{10.1007/s007020050230}}, volume = {{106}}, year = {{1999}}, }