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Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.

Aburawi, Elhadi LU ; Liuba, Petru LU ; Pesonen, Erkki LU and Sjöblad, Sture LU (2004) In Diabetes Care 27(11). p.2733-2735
Abstract
Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).



Notably, type 1 diabetes increases the propensity for both chronic and acute... (More)
Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).



Notably, type 1 diabetes increases the propensity for both chronic and acute infections in part by weakening the immune mechanisms (6). The risk is particularly increased for respiratory tract infections, but other infections have also been associated with diabetes (7). Furthermore, diabetic patients are at greater risk for infection-related mortality (8), and the excess risk appears to be linked to cardiovascular diseases (9). In the present study, we investigated whether viral respiratory tract infections in children with type 1 diabetes might impose an additional burden on the arterial endothelial function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
27
issue
11
pages
2733 - 2735
publisher
American Diabetes Association
external identifiers
  • pmid:15505014
  • wos:000224825800027
  • scopus:7444272471
ISSN
1935-5548
DOI
10.2337/diacare.27.11.2733
language
English
LU publication?
yes
id
aae5f406-b246-4497-9d76-5e34707f0302 (old id 129682)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15505014&dopt=Abstract
date added to LUP
2007-07-17 15:59:53
date last changed
2017-01-01 07:01:56
@article{aae5f406-b246-4497-9d76-5e34707f0302,
  abstract     = {Despite improvements in therapy for children with type 1 diabetes, the prevalence of cardiovascular morbidity in adulthood due to accelerated atherosclerosis remains significant (1). Similar to other cardiovascular risk factors, the diabetic state facilitates arterial endothelial injury, a primary event in the pathogenesis of atherosclerosis (2). Although several pediatric studies have reported an association of diabetes with arterial endothelial dysfunction (3,4), pathogenic animal studies have suggested that even though this disease predisposes to endothelial dysfunction and atherosclerosis, it might not be sufficient to cause them (5).<br/><br>
<br/><br>
Notably, type 1 diabetes increases the propensity for both chronic and acute infections in part by weakening the immune mechanisms (6). The risk is particularly increased for respiratory tract infections, but other infections have also been associated with diabetes (7). Furthermore, diabetic patients are at greater risk for infection-related mortality (8), and the excess risk appears to be linked to cardiovascular diseases (9). In the present study, we investigated whether viral respiratory tract infections in children with type 1 diabetes might impose an additional burden on the arterial endothelial function.},
  author       = {Aburawi, Elhadi and Liuba, Petru and Pesonen, Erkki and Sjöblad, Sture},
  issn         = {1935-5548},
  language     = {eng},
  number       = {11},
  pages        = {2733--2735},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Acute respiratory viral infections aggravate arterial endothelial dysfunction in children with type 1 diabetes.},
  url          = {http://dx.doi.org/10.2337/diacare.27.11.2733},
  volume       = {27},
  year         = {2004},
}