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Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children

Holmquist, Peter LU ; Torffvit, Ole LU ; Jorgensen, P.E.; Torring, N.; Nexo, E. and Sjöblad, Sture LU (2001) In Pediatric Nephrology 16(6). p.488-492
Abstract
Both glomerular and tubular markers have been used to follow diabetic nephropathy. However, neither albumin nor proximal tubular markers have proven useful in prepubertal diabetes. Hence we studied two markers derived from the distal tubular cells, Tamm-Horsfall protein (THP) and epidermal growth factor (EGF), The urinary excretion of THP and EGF was examined in samples obtained during the first 20 days and 1 year after diagnosis of diabetes in children aged 4-15 years. Fourteen children without and 18 with ketonuria were examined, and 17 age-matched healthy children participated as controls. The excretion rate of EGF was increased at diagnosis, while that of THP was not. After 20 days of treatment the excretion of EGF had normalized,... (More)
Both glomerular and tubular markers have been used to follow diabetic nephropathy. However, neither albumin nor proximal tubular markers have proven useful in prepubertal diabetes. Hence we studied two markers derived from the distal tubular cells, Tamm-Horsfall protein (THP) and epidermal growth factor (EGF), The urinary excretion of THP and EGF was examined in samples obtained during the first 20 days and 1 year after diagnosis of diabetes in children aged 4-15 years. Fourteen children without and 18 with ketonuria were examined, and 17 age-matched healthy children participated as controls. The excretion rate of EGF was increased at diagnosis, while that of THP was not. After 20 days of treatment the excretion of EGF had normalized, while the excretion of THP was decreased. Similar results were obtained after 1 year. In conclusion, in spite of good metabolic control a reduced excretion of THP persisted for at least 1 year after the diagnosis of diabetes. Whether the finding of reduced excretion of THP has any biological significance awaits further study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Nephrology
volume
16
issue
6
pages
488 - 492
publisher
Springer
external identifiers
  • wos:000169274800005
  • scopus:0034991314
ISSN
1432-198X
DOI
10.1007/s004670100587
language
English
LU publication?
yes
id
1a73b34b-3586-44f2-a617-d2a8db570a44 (old id 1297056)
date added to LUP
2009-07-15 11:01:59
date last changed
2018-01-07 08:59:03
@article{1a73b34b-3586-44f2-a617-d2a8db570a44,
  abstract     = {Both glomerular and tubular markers have been used to follow diabetic nephropathy. However, neither albumin nor proximal tubular markers have proven useful in prepubertal diabetes. Hence we studied two markers derived from the distal tubular cells, Tamm-Horsfall protein (THP) and epidermal growth factor (EGF), The urinary excretion of THP and EGF was examined in samples obtained during the first 20 days and 1 year after diagnosis of diabetes in children aged 4-15 years. Fourteen children without and 18 with ketonuria were examined, and 17 age-matched healthy children participated as controls. The excretion rate of EGF was increased at diagnosis, while that of THP was not. After 20 days of treatment the excretion of EGF had normalized, while the excretion of THP was decreased. Similar results were obtained after 1 year. In conclusion, in spite of good metabolic control a reduced excretion of THP persisted for at least 1 year after the diagnosis of diabetes. Whether the finding of reduced excretion of THP has any biological significance awaits further study.},
  author       = {Holmquist, Peter and Torffvit, Ole and Jorgensen, P.E. and Torring, N. and Nexo, E. and Sjöblad, Sture},
  issn         = {1432-198X},
  language     = {eng},
  number       = {6},
  pages        = {488--492},
  publisher    = {Springer},
  series       = {Pediatric Nephrology},
  title        = {Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children},
  url          = {http://dx.doi.org/10.1007/s004670100587},
  volume       = {16},
  year         = {2001},
}