Advanced

Dose resolution in radiotherapy polymer gel dosimetry: effect of echo spacing in MRI pulse sequence

Baldoc, C; Lepage, M; Bäck, Sven LU ; Murry, P J; Jayasekera, P M; Porter, D and Kron, T (2001) In Physics in Medicine and Biology 46(2). p.449-460
Abstract
In polymer gel dosimetry using magnetic resonance imaging, the uncertainty in absorbed dose is dependent on the experimental determination of T2. The concept of dose resolution (Dpdelta) of polymer gel dosimeters is developed and applied to the uncertainty in dose related to the uncertainty in T2 from a range of T4 encountered in polymer gel dosimetry. Dpdelta is defined as the minimal separation between two absorbed doses such that they may be distinguished with a given level of confidence, p. The minimum detectable dose (MDD) is Dpdelta as the dose approaches zero. Dpdelta and the minimum detectable dose both give a quantifiable indication of the likely practical limitations and usefulness of the dosimeter. Dpdelta of a polyacrylamide... (More)
In polymer gel dosimetry using magnetic resonance imaging, the uncertainty in absorbed dose is dependent on the experimental determination of T2. The concept of dose resolution (Dpdelta) of polymer gel dosimeters is developed and applied to the uncertainty in dose related to the uncertainty in T2 from a range of T4 encountered in polymer gel dosimetry. Dpdelta is defined as the minimal separation between two absorbed doses such that they may be distinguished with a given level of confidence, p. The minimum detectable dose (MDD) is Dpdelta as the dose approaches zero. Dpdelta and the minimum detectable dose both give a quantifiable indication of the likely practical limitations and usefulness of the dosimeter. Dpdelta of a polyacrylamide polymer gel dosimeter is presented for customized 32-echo and standard multiple-spin-echo sequences on a clinical MRI scanner. In evaluating uncertainties in T2, a parameter of particular significance in the pulse sequence is the echo spacing (ES). For optimal results, ES should be selected to minimize Dpdelta over a range of doses of interest in polymer gel dosimetry. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
46
issue
2
pages
449 - 460
publisher
IOP Publishing
external identifiers
  • wos:000167070200012
  • scopus:0035135245
ISSN
1361-6560
DOI
10.1088/0031-9155/46/2/312
language
English
LU publication?
yes
id
1a3eb24f-df53-412b-bd0c-ee60fcdb81de (old id 1297236)
date added to LUP
2009-07-15 09:39:04
date last changed
2018-03-25 03:31:41
@article{1a3eb24f-df53-412b-bd0c-ee60fcdb81de,
  abstract     = {In polymer gel dosimetry using magnetic resonance imaging, the uncertainty in absorbed dose is dependent on the experimental determination of T2. The concept of dose resolution (Dpdelta) of polymer gel dosimeters is developed and applied to the uncertainty in dose related to the uncertainty in T2 from a range of T4 encountered in polymer gel dosimetry. Dpdelta is defined as the minimal separation between two absorbed doses such that they may be distinguished with a given level of confidence, p. The minimum detectable dose (MDD) is Dpdelta as the dose approaches zero. Dpdelta and the minimum detectable dose both give a quantifiable indication of the likely practical limitations and usefulness of the dosimeter. Dpdelta of a polyacrylamide polymer gel dosimeter is presented for customized 32-echo and standard multiple-spin-echo sequences on a clinical MRI scanner. In evaluating uncertainties in T2, a parameter of particular significance in the pulse sequence is the echo spacing (ES). For optimal results, ES should be selected to minimize Dpdelta over a range of doses of interest in polymer gel dosimetry.},
  author       = {Baldoc, C and Lepage, M and Bäck, Sven and Murry, P J and Jayasekera, P M and Porter, D and Kron, T},
  issn         = {1361-6560},
  language     = {eng},
  number       = {2},
  pages        = {449--460},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {Dose resolution in radiotherapy polymer gel dosimetry: effect of echo spacing in MRI pulse sequence},
  url          = {http://dx.doi.org/10.1088/0031-9155/46/2/312},
  volume       = {46},
  year         = {2001},
}