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Tobacco smoking increases dramatically air concentrations of endotoxin.

Larsson, Lennart LU ; Szponar, Bogumila LU and Pehrson, Christina LU (2004) In Indoor Air 14(6). p.421-424
Abstract
We used a mass spectrometry-based assay for identifying the endotoxin (lipopolysaccharide, LPS) marker (R)-3-hydroxytetradecanoic acid in cigarette smoke particles and found that smoking involved inhalation of 17.4 pmol of endotoxin per each smoked cigarette. Indoor exposure to environmental tobacco smoke (ETS) entailed inhalation of 12.1 pmol of LPS/m3 air, an amount that was 120 times higher than the levels found in smoke-free indoor air. Endotoxin is one of the most potent inflammatory agents known, hence our results may help to explain the high prevalence of respiratory disorders among smokers, and they may also draw attention to a hitherto unknown or neglected risk factor of ETS.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Indoor Air
volume
14
issue
6
pages
421 - 424
publisher
Wiley-Blackwell
external identifiers
  • pmid:15500635
  • wos:000224633900007
  • scopus:8744300771
ISSN
0905-6947
DOI
10.1111/j.1600-0668.2004.00290.x
language
English
LU publication?
yes
id
10d76abb-69d7-4fa8-aae9-e61d43b30d5e (old id 129725)
date added to LUP
2007-07-10 07:38:35
date last changed
2017-09-17 06:59:04
@article{10d76abb-69d7-4fa8-aae9-e61d43b30d5e,
  abstract     = {We used a mass spectrometry-based assay for identifying the endotoxin (lipopolysaccharide, LPS) marker (R)-3-hydroxytetradecanoic acid in cigarette smoke particles and found that smoking involved inhalation of 17.4 pmol of endotoxin per each smoked cigarette. Indoor exposure to environmental tobacco smoke (ETS) entailed inhalation of 12.1 pmol of LPS/m3 air, an amount that was 120 times higher than the levels found in smoke-free indoor air. Endotoxin is one of the most potent inflammatory agents known, hence our results may help to explain the high prevalence of respiratory disorders among smokers, and they may also draw attention to a hitherto unknown or neglected risk factor of ETS.},
  author       = {Larsson, Lennart and Szponar, Bogumila and Pehrson, Christina},
  issn         = {0905-6947},
  language     = {eng},
  number       = {6},
  pages        = {421--424},
  publisher    = {Wiley-Blackwell},
  series       = {Indoor Air},
  title        = {Tobacco smoking increases dramatically air concentrations of endotoxin.},
  url          = {http://dx.doi.org/10.1111/j.1600-0668.2004.00290.x},
  volume       = {14},
  year         = {2004},
}