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Preeclampsia--abnormal uterine artery Doppler is related to recurrence of symptoms during the next pregnancy.

Gudmundsson, Saemundur LU ; Dubiel, M and Gudnasson, H M (2004) In Journal of Perinatal Medicine 32(5). p.400-403
Abstract
Background: Impaired trophoblast invasion is suggested as the main cause of reduced placental perfusion, which results in fetal growth restriction and preeclampsia. Immunological response against the invading tissue has been given as the explanation. Preeclampsia frequently recurs during the next pregnancy. Doppler ultrasound can predict increased vascular impedance in the uteroplacental circulation. Whether signs of increased vascular resistance in pregnancies complicated by preeclampsia are predictive of recurrence during the next pregnancy is unknown. Methods and material: Uterine artery Doppler was performed in 570 pregnant women with preeclampsia. Of these, 139 became pregnant again. The uterine artery Doppler results during the first... (More)
Background: Impaired trophoblast invasion is suggested as the main cause of reduced placental perfusion, which results in fetal growth restriction and preeclampsia. Immunological response against the invading tissue has been given as the explanation. Preeclampsia frequently recurs during the next pregnancy. Doppler ultrasound can predict increased vascular impedance in the uteroplacental circulation. Whether signs of increased vascular resistance in pregnancies complicated by preeclampsia are predictive of recurrence during the next pregnancy is unknown. Methods and material: Uterine artery Doppler was performed in 570 pregnant women with preeclampsia. Of these, 139 became pregnant again. The uterine artery Doppler results during the first pregnancy were related to symptoms of preeclampsia in the succeeding pregnancy. Results: Preeclampsia developed again in 43 of the 139 women. Pregnancies with signs of increased uterine artery vascular impedance during the first pregnancy were 3.4 times more likely to develop preeclampsia again (CI 1.587.6). Similar results for a small for gestational age newborn were 9.7 (CI 1.190). Conclusion: Increased uterine artery vascular impedance in pregnancies complicated by preeclampsia increases the likelihood of recurrence and growth restriction during the next pregnancy. The Doppler information gathered during the first pregnancy might thus select cases for special surveillance and possibly prophylactic antiplatelet treatment in the next pregnancy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Perinatal Medicine
volume
32
issue
5
pages
400 - 403
publisher
De Gruyter
external identifiers
  • pmid:15493714
  • wos:000223659800002
  • scopus:4644353129
ISSN
1619-3997
DOI
10.1515/JPM.2004.135
language
English
LU publication?
yes
id
d189d51a-6292-49ca-b28d-ee2559619187 (old id 129755)
alternative location
http://www.degruyter.de/journals/jpm/jpm32_5.html
date added to LUP
2007-07-23 11:18:07
date last changed
2017-01-01 04:38:18
@article{d189d51a-6292-49ca-b28d-ee2559619187,
  abstract     = {Background: Impaired trophoblast invasion is suggested as the main cause of reduced placental perfusion, which results in fetal growth restriction and preeclampsia. Immunological response against the invading tissue has been given as the explanation. Preeclampsia frequently recurs during the next pregnancy. Doppler ultrasound can predict increased vascular impedance in the uteroplacental circulation. Whether signs of increased vascular resistance in pregnancies complicated by preeclampsia are predictive of recurrence during the next pregnancy is unknown. Methods and material: Uterine artery Doppler was performed in 570 pregnant women with preeclampsia. Of these, 139 became pregnant again. The uterine artery Doppler results during the first pregnancy were related to symptoms of preeclampsia in the succeeding pregnancy. Results: Preeclampsia developed again in 43 of the 139 women. Pregnancies with signs of increased uterine artery vascular impedance during the first pregnancy were 3.4 times more likely to develop preeclampsia again (CI 1.587.6). Similar results for a small for gestational age newborn were 9.7 (CI 1.190). Conclusion: Increased uterine artery vascular impedance in pregnancies complicated by preeclampsia increases the likelihood of recurrence and growth restriction during the next pregnancy. The Doppler information gathered during the first pregnancy might thus select cases for special surveillance and possibly prophylactic antiplatelet treatment in the next pregnancy.},
  author       = {Gudmundsson, Saemundur and Dubiel, M and Gudnasson, H M},
  issn         = {1619-3997},
  language     = {eng},
  number       = {5},
  pages        = {400--403},
  publisher    = {De Gruyter},
  series       = {Journal of Perinatal Medicine},
  title        = {Preeclampsia--abnormal uterine artery Doppler is related to recurrence of symptoms during the next pregnancy.},
  url          = {http://dx.doi.org/10.1515/JPM.2004.135},
  volume       = {32},
  year         = {2004},
}