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Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia

Nägga, Katarina LU ; Rajani, R; Mardh, E; Borch, K; Mardh, S and Marcusson, J (2003) In Dementia and Geriatric Cognitive Disorders 16(4). p.269-275
Abstract
The prevalence of dementia disorders, cobalamin and/or folate deficiency as well as gastritis increases with age. To investigate whether there is an association between these conditions, plasma homocysteine (Hcy), serum methylmalonic acid, serum cobalamin and blood folate concentrations were measured. Gastritis was indirectly diagnosed by measuring serum antibodies against H,K-ATPase, HELICOBACTER PYLORI and intrinsic factor, using enzyme-linked immunosorbent assays. The studied groups consisted of 47 patients with Alzheimer's disease (AD), 9 with AD pathology in combination with additive vascular lesions, 59 with vascular dementia, 8 who were cognitively impaired, and 101 control cases. Plasma Hcy concentrations were significantly... (More)
The prevalence of dementia disorders, cobalamin and/or folate deficiency as well as gastritis increases with age. To investigate whether there is an association between these conditions, plasma homocysteine (Hcy), serum methylmalonic acid, serum cobalamin and blood folate concentrations were measured. Gastritis was indirectly diagnosed by measuring serum antibodies against H,K-ATPase, HELICOBACTER PYLORI and intrinsic factor, using enzyme-linked immunosorbent assays. The studied groups consisted of 47 patients with Alzheimer's disease (AD), 9 with AD pathology in combination with additive vascular lesions, 59 with vascular dementia, 8 who were cognitively impaired, and 101 control cases. Plasma Hcy concentrations were significantly elevated in the dementia groups, with the highest levels in patients with vascular pathology. We conclude that hyperhomocysteinemia is a common finding in patients with dementia disorders of different etiologies. The markers for gastritis did not contribute to an elucidation of a possible connection between this condition, dementia disorders, or cobalamin/folate deficiency. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
16
issue
4
pages
269 - 275
publisher
Karger
external identifiers
  • wos:000185736500013
  • scopus:17544385370
ISSN
1420-8008
DOI
10.1159/000072812
language
English
LU publication?
no
id
0679f1fd-726c-453f-94f7-b90706e6c0ca (old id 1297697)
date added to LUP
2009-07-14 10:23:38
date last changed
2018-01-07 05:51:53
@article{0679f1fd-726c-453f-94f7-b90706e6c0ca,
  abstract     = {The prevalence of dementia disorders, cobalamin and/or folate deficiency as well as gastritis increases with age. To investigate whether there is an association between these conditions, plasma homocysteine (Hcy), serum methylmalonic acid, serum cobalamin and blood folate concentrations were measured. Gastritis was indirectly diagnosed by measuring serum antibodies against H,K-ATPase, HELICOBACTER PYLORI and intrinsic factor, using enzyme-linked immunosorbent assays. The studied groups consisted of 47 patients with Alzheimer's disease (AD), 9 with AD pathology in combination with additive vascular lesions, 59 with vascular dementia, 8 who were cognitively impaired, and 101 control cases. Plasma Hcy concentrations were significantly elevated in the dementia groups, with the highest levels in patients with vascular pathology. We conclude that hyperhomocysteinemia is a common finding in patients with dementia disorders of different etiologies. The markers for gastritis did not contribute to an elucidation of a possible connection between this condition, dementia disorders, or cobalamin/folate deficiency.},
  author       = {Nägga, Katarina and Rajani, R and Mardh, E and Borch, K and Mardh, S and Marcusson, J},
  issn         = {1420-8008},
  language     = {eng},
  number       = {4},
  pages        = {269--275},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia},
  url          = {http://dx.doi.org/10.1159/000072812},
  volume       = {16},
  year         = {2003},
}