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Presentation of laboratory and sonoclot variables using principal component analysis: identification of hypo- and hypercoagulation in the HELLP syndrome

Liszka-Hackzell, John J and Schött, Ulf LU (2005) In Journal of Clinical Monitoring and Computing 18(4). p.247-252
Abstract
The HELLP (Hemolysis, Elevated Liver enzyme, and Low Platelet) syndrome requires close monitoring of rapid changes in hemostasis. A bedside viscoelastic test--Sonoclot--was used together with coagulation, liver and hemolysis laboratory analyses in three parturients with the HELLP syndrome up to 10 days postpartum. Principal component analysis (PCA) was used to reduce the dimensionality of this multivariate problem and to visualize this process in a two-dimensional plot. It was possible to follow changes in these variables over time and to show how they changed in relation to 10 typical healthy parturients with normal laboratory and Sonoclot values as well as 20 simulated patients with hypo- or hypercoagubility. The effects of emergency... (More)
The HELLP (Hemolysis, Elevated Liver enzyme, and Low Platelet) syndrome requires close monitoring of rapid changes in hemostasis. A bedside viscoelastic test--Sonoclot--was used together with coagulation, liver and hemolysis laboratory analyses in three parturients with the HELLP syndrome up to 10 days postpartum. Principal component analysis (PCA) was used to reduce the dimensionality of this multivariate problem and to visualize this process in a two-dimensional plot. It was possible to follow changes in these variables over time and to show how they changed in relation to 10 typical healthy parturients with normal laboratory and Sonoclot values as well as 20 simulated patients with hypo- or hypercoagubility. The effects of emergency delivery, correction of low plasma-antithrombin with plasma and antithrombin factor concentrate, plasma exchange and individualized dosages of low molecular weight heparin to counteract postpartum Sonoclot detected hypercoagulation were evaluated. The efficiency of each treatment strategy was visualized in the PCA plot by movement towards an area with normocoagulation. In conclusion, PCA of viscoelastic and laboratory coagulation analysis data facilitated the detection of both hypo- and hypercoagulative events and represents an alternative way to evaluate treatment strategies in patients with complex coagulative disorders, like the HELLP syndrome. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Monitoring and Computing
volume
18
issue
4
pages
247 - 252
publisher
Springer
external identifiers
  • scopus:15344350093
ISSN
1573-2614
DOI
10.1007/s10877-005-9046-0
language
English
LU publication?
no
id
e6ad013a-ba10-4217-9b9b-a1c4fdfcaf28 (old id 1297856)
date added to LUP
2009-07-14 08:21:47
date last changed
2017-01-01 06:53:43
@article{e6ad013a-ba10-4217-9b9b-a1c4fdfcaf28,
  abstract     = {The HELLP (Hemolysis, Elevated Liver enzyme, and Low Platelet) syndrome requires close monitoring of rapid changes in hemostasis. A bedside viscoelastic test--Sonoclot--was used together with coagulation, liver and hemolysis laboratory analyses in three parturients with the HELLP syndrome up to 10 days postpartum. Principal component analysis (PCA) was used to reduce the dimensionality of this multivariate problem and to visualize this process in a two-dimensional plot. It was possible to follow changes in these variables over time and to show how they changed in relation to 10 typical healthy parturients with normal laboratory and Sonoclot values as well as 20 simulated patients with hypo- or hypercoagubility. The effects of emergency delivery, correction of low plasma-antithrombin with plasma and antithrombin factor concentrate, plasma exchange and individualized dosages of low molecular weight heparin to counteract postpartum Sonoclot detected hypercoagulation were evaluated. The efficiency of each treatment strategy was visualized in the PCA plot by movement towards an area with normocoagulation. In conclusion, PCA of viscoelastic and laboratory coagulation analysis data facilitated the detection of both hypo- and hypercoagulative events and represents an alternative way to evaluate treatment strategies in patients with complex coagulative disorders, like the HELLP syndrome.},
  author       = {Liszka-Hackzell, John J and Schött, Ulf},
  issn         = {1573-2614},
  language     = {eng},
  number       = {4},
  pages        = {247--252},
  publisher    = {Springer},
  series       = {Journal of Clinical Monitoring and Computing},
  title        = {Presentation of laboratory and sonoclot variables using principal component analysis: identification of hypo- and hypercoagulation in the HELLP syndrome},
  url          = {http://dx.doi.org/10.1007/s10877-005-9046-0},
  volume       = {18},
  year         = {2005},
}