Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza
(2022) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 130(9). p.590-596- Abstract
Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in... (More)
Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared with bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared with the other etiologies (p < 0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared with those infected with bacteria. Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared with those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.
(Less)
- author
- publishing date
- 2022-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers/blood, C-Reactive Protein/metabolism, COVID-19/complications, Community-Acquired Infections/blood, Cross-Sectional Studies, Ferritins, Hepcidins/metabolism, Humans, Influenza, Human/complications, Iron/metabolism, Pneumonia, Bacterial/blood, Pneumonia, Viral/blood, SARS-CoV-2
- in
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- volume
- 130
- issue
- 9
- pages
- 590 - 596
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85135058508
- pmid:35751642
- ISSN
- 0903-4641
- DOI
- 10.1111/apm.13259
- language
- English
- LU publication?
- no
- additional info
- © 2022 APMIS. Published by John Wiley & Sons Ltd.
- id
- 1297f535-ba74-4db5-b7ed-2fa12aa346d4
- date added to LUP
- 2024-10-14 09:25:52
- date last changed
- 2024-10-15 04:01:17
@article{1297f535-ba74-4db5-b7ed-2fa12aa346d4,
abstract = {{<p>Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared with bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared with the other etiologies (p < 0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared with those infected with bacteria. Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared with those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.</p>}},
author = {{Hegelund, Maria Hein and Glenthøj, Andreas and Ryrsø, Camilla Koch and Ritz, Christian and Dungu, Arnold Matovu and Sejdic, Adin and List, Karoline Cecilie Knudsen and Krogh-Madsen, Rikke and Lindegaard, Birgitte and Kurtzhals, Jørgen Anders Lindholm and Faurholt-Jepsen, Daniel}},
issn = {{0903-4641}},
keywords = {{Biomarkers/blood; C-Reactive Protein/metabolism; COVID-19/complications; Community-Acquired Infections/blood; Cross-Sectional Studies; Ferritins; Hepcidins/metabolism; Humans; Influenza, Human/complications; Iron/metabolism; Pneumonia, Bacterial/blood; Pneumonia, Viral/blood; SARS-CoV-2}},
language = {{eng}},
number = {{9}},
pages = {{590--596}},
publisher = {{John Wiley & Sons Inc.}},
series = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
title = {{Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza}},
url = {{http://dx.doi.org/10.1111/apm.13259}},
doi = {{10.1111/apm.13259}},
volume = {{130}},
year = {{2022}},
}