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Evaluation of factors of importance for clinical dementia diagnosis

Nägga, Katarina LU ; Garcia, Jorge; Zetterberg, Henrik; Blennow, Kaj; Gottfries, Johan and Marcusson, Jan (2005) In Dementia and Geriatric Cognitive Disorders 19(5-6). p.289-298
Abstract
Diagnosing clinical dementia is based on an assessment of different variables, such as the patient's medical history, known risk factors, and biochemical features. Partial least squares discriminant analysis was used to evaluate variables of importance for diagnosing dementia in a clinical dementia population. Polymorphism for genotypes of glutathione S-transferase (GST) and sulfotransferase 1A1, hypothetically of importance in dementia disorders, was also included in the analysis. The study population consisted of 73 patients with Alzheimer's disease (AD), 14 with mixed dementia, 75 patients with vascular dementia, and 28 control cases. We found that several of the variables, such as the presence of ApoE4 allele, high cerebrospinal fluid... (More)
Diagnosing clinical dementia is based on an assessment of different variables, such as the patient's medical history, known risk factors, and biochemical features. Partial least squares discriminant analysis was used to evaluate variables of importance for diagnosing dementia in a clinical dementia population. Polymorphism for genotypes of glutathione S-transferase (GST) and sulfotransferase 1A1, hypothetically of importance in dementia disorders, was also included in the analysis. The study population consisted of 73 patients with Alzheimer's disease (AD), 14 with mixed dementia, 75 patients with vascular dementia, and 28 control cases. We found that several of the variables, such as the presence of ApoE4 allele, high cerebrospinal fluid levels of total tau protein, low levels of beta-amyloid((1-42)), and a low score on the Mini-Mental State Examination, facilitated a discrimination between the diagnoses compared with the controls. The different diagnoses overlapped. There were indications that genotypes of GSTs contributed to a subgrouping within AD. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
19
issue
5-6
pages
289 - 298
publisher
Karger
external identifiers
  • wos:000228848200007
  • scopus:18644363457
ISSN
1420-8008
DOI
10.1159/000084554
language
English
LU publication?
no
id
c77de21e-7587-4e7e-a3e6-ec1f4becbc25 (old id 1298084)
date added to LUP
2009-07-13 11:21:59
date last changed
2017-01-01 04:23:26
@article{c77de21e-7587-4e7e-a3e6-ec1f4becbc25,
  abstract     = {Diagnosing clinical dementia is based on an assessment of different variables, such as the patient's medical history, known risk factors, and biochemical features. Partial least squares discriminant analysis was used to evaluate variables of importance for diagnosing dementia in a clinical dementia population. Polymorphism for genotypes of glutathione S-transferase (GST) and sulfotransferase 1A1, hypothetically of importance in dementia disorders, was also included in the analysis. The study population consisted of 73 patients with Alzheimer's disease (AD), 14 with mixed dementia, 75 patients with vascular dementia, and 28 control cases. We found that several of the variables, such as the presence of ApoE4 allele, high cerebrospinal fluid levels of total tau protein, low levels of beta-amyloid((1-42)), and a low score on the Mini-Mental State Examination, facilitated a discrimination between the diagnoses compared with the controls. The different diagnoses overlapped. There were indications that genotypes of GSTs contributed to a subgrouping within AD.},
  author       = {Nägga, Katarina and Garcia, Jorge and Zetterberg, Henrik and Blennow, Kaj and Gottfries, Johan and Marcusson, Jan},
  issn         = {1420-8008},
  language     = {eng},
  number       = {5-6},
  pages        = {289--298},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Evaluation of factors of importance for clinical dementia diagnosis},
  url          = {http://dx.doi.org/10.1159/000084554},
  volume       = {19},
  year         = {2005},
}