Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function
(2006) In Cellular Microbiology 8(2). p.316-325- Abstract
- Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the GlcNAc(beta1-3)-Gal(beta1-4)-Glc-R oligosaccharide outer core of lgtB LPS with the dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) lectin receptor. Activation of DC-SIGN with this novel oligosaccharide ligand skewed T-cell responses driven by DC towards T helper type 1 activity. Thus, the use of lgtB LPS may provide a powerful instrument to... (More)
- Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the GlcNAc(beta1-3)-Gal(beta1-4)-Glc-R oligosaccharide outer core of lgtB LPS with the dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) lectin receptor. Activation of DC-SIGN with this novel oligosaccharide ligand skewed T-cell responses driven by DC towards T helper type 1 activity. Thus, the use of lgtB LPS may provide a powerful instrument to selectively induce the desired arm of the immune response and potentially increase vaccine efficacy. (Less)
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https://lup.lub.lu.se/record/1298383
- author
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular Microbiology
- volume
- 8
- issue
- 2
- pages
- 316 - 325
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000234667200013
- scopus:33644821162
- ISSN
- 1462-5814
- DOI
- 10.1111/j.1462-5822.2005.00623.x
- language
- English
- LU publication?
- no
- id
- 96c24b5f-4052-4960-9a3d-23d9a58d3fb1 (old id 1298383)
- date added to LUP
- 2016-04-04 10:06:36
- date last changed
- 2022-03-23 07:29:46
@article{96c24b5f-4052-4960-9a3d-23d9a58d3fb1, abstract = {{Neisseria meningitidis lipopolysaccharide (LPS) has been identified as a major determinant of dendritic cell (DC) function. Here we report that one of a series of meningococcal mutants with defined truncations in the lacto-N-neotetraose outer core of the LPS exhibited unique strong adhesion and internalization properties towards DC. These properties were mediated by interaction of the GlcNAc(beta1-3)-Gal(beta1-4)-Glc-R oligosaccharide outer core of lgtB LPS with the dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) lectin receptor. Activation of DC-SIGN with this novel oligosaccharide ligand skewed T-cell responses driven by DC towards T helper type 1 activity. Thus, the use of lgtB LPS may provide a powerful instrument to selectively induce the desired arm of the immune response and potentially increase vaccine efficacy.}}, author = {{Steeghs, Liana and van Vliet, Sandra and Uronen-Hansson, Heli and van Mourik, Andries and Engering, Anneke and Sanchez-Hernandez, Martha and Klein, Nigel and Callard, Robin and van Putten, Jos P M and van der Ley, Peter and van Kooyk, Yvette and van de Winkel, Jan G J}}, issn = {{1462-5814}}, language = {{eng}}, number = {{2}}, pages = {{316--325}}, publisher = {{Wiley-Blackwell}}, series = {{Cellular Microbiology}}, title = {{Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function}}, url = {{http://dx.doi.org/10.1111/j.1462-5822.2005.00623.x}}, doi = {{10.1111/j.1462-5822.2005.00623.x}}, volume = {{8}}, year = {{2006}}, }