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Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

Llorens, Franc ; Hermann, Peter ; Villar-Piqué, Anna ; Diaz-Lucena, Daniela ; Nägga, Katarina LU ; Hansson, Oskar LU ; Santana, Isabel ; Schmitz, Matthias ; Schmidt, Christian and Varges, Daniela , et al. (2020) In Nature Communications 11.
Abstract

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer’s disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high... (More)

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer’s disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias.

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type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
11
article number
619
publisher
Nature Publishing Group
external identifiers
  • scopus:85078710065
  • pmid:32001681
ISSN
2041-1723
DOI
10.1038/s41467-020-14373-2
language
English
LU publication?
yes
id
12abef50-a082-4d1f-9469-bea381f7b16c
date added to LUP
2020-02-11 09:45:50
date last changed
2021-01-26 03:25:07
@article{12abef50-a082-4d1f-9469-bea381f7b16c,
  abstract     = {<p>The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer’s disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias.</p>},
  author       = {Llorens, Franc and Hermann, Peter and Villar-Piqué, Anna and Diaz-Lucena, Daniela and Nägga, Katarina and Hansson, Oskar and Santana, Isabel and Schmitz, Matthias and Schmidt, Christian and Varges, Daniela and Goebel, Stefan and Dumurgier, Julien and Zetterberg, Henrik and Blennow, Kaj and Paquet, Claire and Baldeiras, Inês and Ferrer, Isidro and Zerr, Inga},
  issn         = {2041-1723},
  language     = {eng},
  month        = {01},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia},
  url          = {http://dx.doi.org/10.1038/s41467-020-14373-2},
  doi          = {10.1038/s41467-020-14373-2},
  volume       = {11},
  year         = {2020},
}