Psychiatric morbidity and its impact on surgical outcomes for esophageal and gastric cancer patients : A nationwide cohort study
Song, Huan ; Zhu, Jianwei ; Lu, Donghao ; Fang, Fang ; Ye, Weimin ; Lundell, Lars ; Johansson, Jan LU
; Lindblad, Mats
and Nilsson, Magnus
(2017)
In Oncotarget
8(46).
p.81305-81314
- Abstract
Background: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. Results: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality). Materials and Methods: Based on the Swedish National... (More)
Background: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. Results: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality). Materials and Methods: Based on the Swedish National Registry for Esophageal and Gastric cancer (NREV), we constructed a nationwide prospective cohort containing 2,745 surgically treated patients in 2006-2012. Perioperative psychiatric morbidity was defined as a clinical diagnosis of psychiatric disorder, from two years before to two years after surgery. Using propensity scores, we applied inverse probability of treatment weights (IPTW)-weighted Poisson regression model to evaluate relative risk (RR) of short-term surgical outcomes in relation to perioperative psychiatric morbidity. Further, IPTW-weighted Cox proportional hazards model was used to estimate hazard ratios (HRs) for mortality that occurred after 90 days of surgery. Conclusions: Perioperative psychiatric morbidity could worsen both short-term and long-term surgical outcomes among patients with gastric or esophageal cancer.
(Less)
- author
- Song, Huan
; Zhu, Jianwei
; Lu, Donghao
; Fang, Fang
; Ye, Weimin
; Lundell, Lars
; Johansson, Jan
LU
; Lindblad, Mats
and Nilsson, Magnus
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Esophageal cancer, Gastric cancer, Prognosis, Psychiatric morbidity, Surgery
- in
- Oncotarget
- volume
- 8
- issue
- 46
- pages
- 10 pages
- publisher
- Impact Journals
- external identifiers
-
- scopus:85030653668
- wos:000412465700105
- pmid:29113389
- ISSN
- 1949-2553
- DOI
- 10.18632/oncotarget.18347
- language
- English
- LU publication?
- yes
- id
- 12c24687-74a5-4e4a-b4a4-c7b4e5990a54
- date added to LUP
- 2017-11-07 14:56:11
- date last changed
- 2025-01-08 00:09:41
@article{12c24687-74a5-4e4a-b4a4-c7b4e5990a54,
abstract = {{<p>Background: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. Results: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality). Materials and Methods: Based on the Swedish National Registry for Esophageal and Gastric cancer (NREV), we constructed a nationwide prospective cohort containing 2,745 surgically treated patients in 2006-2012. Perioperative psychiatric morbidity was defined as a clinical diagnosis of psychiatric disorder, from two years before to two years after surgery. Using propensity scores, we applied inverse probability of treatment weights (IPTW)-weighted Poisson regression model to evaluate relative risk (RR) of short-term surgical outcomes in relation to perioperative psychiatric morbidity. Further, IPTW-weighted Cox proportional hazards model was used to estimate hazard ratios (HRs) for mortality that occurred after 90 days of surgery. Conclusions: Perioperative psychiatric morbidity could worsen both short-term and long-term surgical outcomes among patients with gastric or esophageal cancer.</p>}},
author = {{Song, Huan and Zhu, Jianwei and Lu, Donghao and Fang, Fang and Ye, Weimin and Lundell, Lars and Johansson, Jan and Lindblad, Mats and Nilsson, Magnus}},
issn = {{1949-2553}},
keywords = {{Esophageal cancer; Gastric cancer; Prognosis; Psychiatric morbidity; Surgery}},
language = {{eng}},
number = {{46}},
pages = {{81305--81314}},
publisher = {{Impact Journals}},
series = {{Oncotarget}},
title = {{Psychiatric morbidity and its impact on surgical outcomes for esophageal and gastric cancer patients : A nationwide cohort study}},
url = {{http://dx.doi.org/10.18632/oncotarget.18347}},
doi = {{10.18632/oncotarget.18347}},
volume = {{8}},
year = {{2017}},
}