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Incidence of bullous pemphigoid in Sweden 2005–2012 : a nationwide population-based cohort study of 3761 patients

Thorslund, Kristofer; Seifert, Oliver; Nilzén, Karin and Grönhagen, Carina LU (2017) In Archives of Dermatological Research 309(9). p.721-727
Abstract

Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005–2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). The diagnosis of bullous pemphigoid in the NPR was recently validated from medical records, histopathological and immunopathological data by our group in a previous study. The average annual incidence of bullous pemphigoid was 7.1/100,000 (95% CI 6.5–7.7). Female to male ratio was 1.2:1, mean age at... (More)

Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005–2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). The diagnosis of bullous pemphigoid in the NPR was recently validated from medical records, histopathological and immunopathological data by our group in a previous study. The average annual incidence of bullous pemphigoid was 7.1/100,000 (95% CI 6.5–7.7). Female to male ratio was 1.2:1, mean age at diagnosis was 78.9 years. The age-specific incidence rate increased markedly after 80 years of age with an incidence peak between 90 and 99 years of age, 81.9/100,000 (95% CI 75.0–89.2). This large nationwide cohort study presents an adjusted incidence of BP of 7.1/100,000 (95% CI 6.5–7.7) in Sweden. The incidence of bullous pemphigoid is higher than expected and bullous pemphigoid is a common disease in the elderly population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bullous pemphigoid, Incidence, Population-based cohort study
in
Archives of Dermatological Research
volume
309
issue
9
pages
721 - 727
publisher
Springer
external identifiers
  • scopus:85029001125
  • pmid:28875235
  • wos:000413313300005
ISSN
0340-3696
DOI
10.1007/s00403-017-1778-4
language
English
LU publication?
yes
id
12c922a9-f653-45e7-afca-1a7a802860ba
date added to LUP
2017-10-09 11:38:29
date last changed
2018-04-10 03:00:14
@article{12c922a9-f653-45e7-afca-1a7a802860ba,
  abstract     = {<p>Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005–2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). The diagnosis of bullous pemphigoid in the NPR was recently validated from medical records, histopathological and immunopathological data by our group in a previous study. The average annual incidence of bullous pemphigoid was 7.1/100,000 (95% CI 6.5–7.7). Female to male ratio was 1.2:1, mean age at diagnosis was 78.9 years. The age-specific incidence rate increased markedly after 80 years of age with an incidence peak between 90 and 99 years of age, 81.9/100,000 (95% CI 75.0–89.2). This large nationwide cohort study presents an adjusted incidence of BP of 7.1/100,000 (95% CI 6.5–7.7) in Sweden. The incidence of bullous pemphigoid is higher than expected and bullous pemphigoid is a common disease in the elderly population.</p>},
  author       = {Thorslund, Kristofer and Seifert, Oliver and Nilzén, Karin and Grönhagen, Carina},
  issn         = {0340-3696},
  keyword      = {Bullous pemphigoid,Incidence,Population-based cohort study},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {721--727},
  publisher    = {Springer},
  series       = {Archives of Dermatological Research},
  title        = {Incidence of bullous pemphigoid in Sweden 2005–2012 : a nationwide population-based cohort study of 3761 patients},
  url          = {http://dx.doi.org/10.1007/s00403-017-1778-4},
  volume       = {309},
  year         = {2017},
}