Molecular Mechanisms of L-DOPA-Induced Dyskinesia
Cenci Nilsson, Angela LU
(2017)
In Handbook of Behavioral Neuroscience
24.
p.857-871
- Abstract
The dopamine (DA) precursor, 3,4-dihydroxyphenyl-L-alanine (L-DOPA), is the most effective treatment for Parkinson's disease (PD), but causes dyskinesias (abnormal involuntary movements) in the vast majority of patients. There is a wide consensus that L-DOPA-induced dyskinesia (LID) depends on both pre- and postsynaptic disturbances of the nigrostriatal DA transmission. Presynaptically, LID is associated with abnormal DA release and defective DA clearance, which converge to cause large swings in brain DA levels concomitant with the medication. Postsynaptically, LID is associated with a dysregulation of intracellular signaling and gene expression downstream of the D1 DA receptor. These phenomena are particularly well studied in the... (More)
The dopamine (DA) precursor, 3,4-dihydroxyphenyl-L-alanine (L-DOPA), is the most effective treatment for Parkinson's disease (PD), but causes dyskinesias (abnormal involuntary movements) in the vast majority of patients. There is a wide consensus that L-DOPA-induced dyskinesia (LID) depends on both pre- and postsynaptic disturbances of the nigrostriatal DA transmission. Presynaptically, LID is associated with abnormal DA release and defective DA clearance, which converge to cause large swings in brain DA levels concomitant with the medication. Postsynaptically, LID is associated with a dysregulation of intracellular signaling and gene expression downstream of the D1 DA receptor. These phenomena are particularly well studied in the striatum and are thus the main topic of this chapter. In addition, the chapter reviews studies that have revealed associations between LID and different types of abnormalities in glutamatergic and GABAergic transmission within cortico-basal ganglia circuits.
(Less)
- author
- Cenci Nilsson, Angela
LU
- organization
- publishing date
- 2017
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- animal models, dopamine, gene expression, glutamate, Neurodegenerative disease, neuroplasticity, Parkinson's disease, serotonin, striatum
- host publication
- Handbook of Behavioral Neuroscience
- series title
- Handbook of Behavioral Neuroscience
- volume
- 24
- pages
- 15 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84998704789
- ISSN
- 15697339
- DOI
- 10.1016/B978-0-12-802206-1.00043-X
- language
- English
- LU publication?
- yes
- id
- 12d805ec-c2a7-45b2-95ac-fe52dac9b4e0
- date added to LUP
- 2017-03-17 09:52:42
- date last changed
- 2022-05-02 18:31:02
@inbook{12d805ec-c2a7-45b2-95ac-fe52dac9b4e0,
abstract = {{<p>The dopamine (DA) precursor, 3,4-dihydroxyphenyl-L-alanine (L-DOPA), is the most effective treatment for Parkinson's disease (PD), but causes dyskinesias (abnormal involuntary movements) in the vast majority of patients. There is a wide consensus that L-DOPA-induced dyskinesia (LID) depends on both pre- and postsynaptic disturbances of the nigrostriatal DA transmission. Presynaptically, LID is associated with abnormal DA release and defective DA clearance, which converge to cause large swings in brain DA levels concomitant with the medication. Postsynaptically, LID is associated with a dysregulation of intracellular signaling and gene expression downstream of the D1 DA receptor. These phenomena are particularly well studied in the striatum and are thus the main topic of this chapter. In addition, the chapter reviews studies that have revealed associations between LID and different types of abnormalities in glutamatergic and GABAergic transmission within cortico-basal ganglia circuits.</p>}},
author = {{Cenci Nilsson, Angela}},
booktitle = {{Handbook of Behavioral Neuroscience}},
issn = {{15697339}},
keywords = {{animal models; dopamine; gene expression; glutamate; Neurodegenerative disease; neuroplasticity; Parkinson's disease; serotonin; striatum}},
language = {{eng}},
pages = {{857--871}},
publisher = {{Elsevier}},
series = {{Handbook of Behavioral Neuroscience}},
title = {{Molecular Mechanisms of L-DOPA-Induced Dyskinesia}},
url = {{http://dx.doi.org/10.1016/B978-0-12-802206-1.00043-X}},
doi = {{10.1016/B978-0-12-802206-1.00043-X}},
volume = {{24}},
year = {{2017}},
}