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Drug dissolution rate measurements - evaluation of the rotating disc method.

Kaunisto, Erik LU ; Nilsson, Bernt LU and Axelsson, Anders LU (2009) In Pharmaceutical Development and Technology 14. p.400-408
Abstract
Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model substances. Existing theory for the rotating disc was compared with experiments and a computational fluid dynamics (CFD) model simulating the USP vessel. Simulations showed that it is possible to predict mass transfer controlled drug release rates within the laminar flow regime. Mass transfer coefficients obtained from the CFD model were in better... (More)
Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model substances. Existing theory for the rotating disc was compared with experiments and a computational fluid dynamics (CFD) model simulating the USP vessel. Simulations showed that it is possible to predict mass transfer controlled drug release rates within the laminar flow regime. Mass transfer coefficients obtained from the CFD model were in better agreement with experimental data than those obtained from existing theory. It was concluded that the hydrodynamic boundary layer controlling release rates was in reality thicker than existing theory would suggest. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pharmaceutical Development and Technology
volume
14
pages
400 - 408
publisher
Taylor & Francis
external identifiers
  • wos:000269257100009
  • pmid:19235631
  • scopus:70350639584
ISSN
1083-7450
DOI
10.1080/10837450802712641
language
English
LU publication?
yes
id
45d6a6a4-a8b6-42b8-b7a0-fc97eca15bb4 (old id 1302291)
date added to LUP
2009-03-27 13:17:58
date last changed
2017-03-12 03:51:51
@article{45d6a6a4-a8b6-42b8-b7a0-fc97eca15bb4,
  abstract     = {Dissolution rate measurements are important to understand the behaviour of drugs or drug formulations. Many methods for measuring dissolution rates are available and a good choice should be based on method limitations as well as drug characteristics. In the present study the rotating disc method was critically evaluated for dissolution rate measurements, using aspirin and benzoic acid as model substances. Existing theory for the rotating disc was compared with experiments and a computational fluid dynamics (CFD) model simulating the USP vessel. Simulations showed that it is possible to predict mass transfer controlled drug release rates within the laminar flow regime. Mass transfer coefficients obtained from the CFD model were in better agreement with experimental data than those obtained from existing theory. It was concluded that the hydrodynamic boundary layer controlling release rates was in reality thicker than existing theory would suggest.},
  author       = {Kaunisto, Erik and Nilsson, Bernt and Axelsson, Anders},
  issn         = {1083-7450},
  language     = {eng},
  pages        = {400--408},
  publisher    = {Taylor & Francis},
  series       = {Pharmaceutical Development and Technology},
  title        = {Drug dissolution rate measurements - evaluation of the rotating disc method.},
  url          = {http://dx.doi.org/10.1080/10837450802712641},
  volume       = {14},
  year         = {2009},
}