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TRPV1-mediated itch in seasonal allergic rhinitis.

Alenmyr, Lisa LU ; Högestätt, Edward LU ; Zygmunt, Peter LU and Greiff, Lennart LU (2009) In Allergy 64. p.807-810
Abstract
Background: Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). Aim of the study: To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. Methods: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Moreover, challenges were performed with mustard oil (allylisothiocyanate) and cinnamaldehyde as well as menthol, activators of TRPA1 and TRPM8, respectively. Nasal symptoms were monitored after each challenge and compared with symptoms reported following corresponding sham challenges. Symptoms recorded after challenge... (More)
Background: Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). Aim of the study: To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. Methods: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Moreover, challenges were performed with mustard oil (allylisothiocyanate) and cinnamaldehyde as well as menthol, activators of TRPA1 and TRPM8, respectively. Nasal symptoms were monitored after each challenge and compared with symptoms reported following corresponding sham challenges. Symptoms recorded after challenge prior to pollen season were also compared with challenge-induced symptoms during pollen season. Results: The TRPV1, TRPA1 and TRPM8-activators produced sensory symptoms dominated by pain and smart. During seasonal allergen exposure, but not prior to season, TRPV1-activators also induced itch. Furthermore, the seasonal challenge to the TRPV1-activator olvanil was associated with rhinorrhoea. Conclusion: Patients with allergic rhinitis feature an increased itch response to TRPV1 stimulation at seasonal allergen exposure. We suggest that this reflects part of the hyperresponsiveness that characterizes on-going allergic rhinitis. Intervention with the TRPV1-signalling pathway may offer potential treatments of this condition. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
64
pages
807 - 810
publisher
Wiley-Blackwell
external identifiers
  • wos:000264823200018
  • pmid:19220220
  • scopus:63849087410
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2009.01937.x
language
English
LU publication?
yes
id
b168e5c1-f789-43e4-a680-8e0fda82a845 (old id 1302518)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19220220?dopt=Abstract
date added to LUP
2009-03-03 11:59:31
date last changed
2017-01-01 07:44:21
@article{b168e5c1-f789-43e4-a680-8e0fda82a845,
  abstract     = {Background: Patients with allergic rhinitis may be abnormally sensitive to stimulation of the ion channel transient receptor potential vanilloid-1 (TRPV1). Aim of the study: To examine effects of various TRP ion channel activators on sensory symptoms in allergic rhinitis prior to and during seasonal allergen exposure. Methods: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Moreover, challenges were performed with mustard oil (allylisothiocyanate) and cinnamaldehyde as well as menthol, activators of TRPA1 and TRPM8, respectively. Nasal symptoms were monitored after each challenge and compared with symptoms reported following corresponding sham challenges. Symptoms recorded after challenge prior to pollen season were also compared with challenge-induced symptoms during pollen season. Results: The TRPV1, TRPA1 and TRPM8-activators produced sensory symptoms dominated by pain and smart. During seasonal allergen exposure, but not prior to season, TRPV1-activators also induced itch. Furthermore, the seasonal challenge to the TRPV1-activator olvanil was associated with rhinorrhoea. Conclusion: Patients with allergic rhinitis feature an increased itch response to TRPV1 stimulation at seasonal allergen exposure. We suggest that this reflects part of the hyperresponsiveness that characterizes on-going allergic rhinitis. Intervention with the TRPV1-signalling pathway may offer potential treatments of this condition.},
  author       = {Alenmyr, Lisa and Högestätt, Edward and Zygmunt, Peter and Greiff, Lennart},
  issn         = {1398-9995},
  language     = {eng},
  pages        = {807--810},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {TRPV1-mediated itch in seasonal allergic rhinitis.},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2009.01937.x},
  volume       = {64},
  year         = {2009},
}