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Allergic Airway Inflammation Initiates Long-Term Vascular Remodeling of the Pulmonary Circulation.

Rydell-Törmänen, Kristina LU ; Uller, Lena LU and Erjefält, Jonas LU (2009) In International Archives of Allergy and Immunology1994-01-01+01:00 149(3). p.251-258
Abstract
Background: Asthma and allergic airway inflammation are associated with persistent structural alterations in the bronchi, i.e. airway remodeling. Previous studies have shown that during allergic airway inflammation, similar structural alterations may also be evoked in the pulmonary circulation. However, it remained unknown whether remodeling of the pulmonary circulation is as persistent as airway remodeling. The aim of this study is to investigate the reversibility and resolution of vascular remodeling, induced by allergic airway inflammation. Methods: A validated mouse model of allergic airway inflammation, utilizing ovalbumin as allergen, was employed. Animals were sacrificed 1 day, 1 week or 1 month after the last allergen exposure, and... (More)
Background: Asthma and allergic airway inflammation are associated with persistent structural alterations in the bronchi, i.e. airway remodeling. Previous studies have shown that during allergic airway inflammation, similar structural alterations may also be evoked in the pulmonary circulation. However, it remained unknown whether remodeling of the pulmonary circulation is as persistent as airway remodeling. The aim of this study is to investigate the reversibility and resolution of vascular remodeling, induced by allergic airway inflammation. Methods: A validated mouse model of allergic airway inflammation, utilizing ovalbumin as allergen, was employed. Animals were sacrificed 1 day, 1 week or 1 month after the last allergen exposure, and different parameters of remodeling (smooth muscle mass, proliferation of smooth muscle cells and endothelial cells as well as number of myofibroblasts and procollagen-I-producing cells) were investigated and quantified histologically. Results: Allergen exposure resulted in allergic airway inflammation characterized by a transient leukocyte infiltration and in structural alterations in both airway and vascular compartments. The increase in vascular smooth muscle mass and endothelial proliferation persisted at 1 month after the last allergen exposure. The other parameters and cellular inflammatory response returned to baseline within 1 month after the last allergen challenge. Conclusions: Based on the findings in this study, we conclude that acute allergic airway inflammation, although being initiated from the airways, is able to evoke similar long-term structural alterations in pulmonary vessels as described for bronchi. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Archives of Allergy and Immunology1994-01-01+01:00
volume
149
issue
3
pages
251 - 258
publisher
Karger
external identifiers
  • wos:000264869700009
  • pmid:19218818
  • scopus:59849105162
ISSN
1423-0097
DOI
10.1159/000199721
language
English
LU publication?
yes
id
351dab07-1b83-414a-9a2f-a86dd822c8b1 (old id 1302530)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19218818?dopt=Abstract
date added to LUP
2009-03-03 12:02:12
date last changed
2017-08-06 04:46:02
@article{351dab07-1b83-414a-9a2f-a86dd822c8b1,
  abstract     = {Background: Asthma and allergic airway inflammation are associated with persistent structural alterations in the bronchi, i.e. airway remodeling. Previous studies have shown that during allergic airway inflammation, similar structural alterations may also be evoked in the pulmonary circulation. However, it remained unknown whether remodeling of the pulmonary circulation is as persistent as airway remodeling. The aim of this study is to investigate the reversibility and resolution of vascular remodeling, induced by allergic airway inflammation. Methods: A validated mouse model of allergic airway inflammation, utilizing ovalbumin as allergen, was employed. Animals were sacrificed 1 day, 1 week or 1 month after the last allergen exposure, and different parameters of remodeling (smooth muscle mass, proliferation of smooth muscle cells and endothelial cells as well as number of myofibroblasts and procollagen-I-producing cells) were investigated and quantified histologically. Results: Allergen exposure resulted in allergic airway inflammation characterized by a transient leukocyte infiltration and in structural alterations in both airway and vascular compartments. The increase in vascular smooth muscle mass and endothelial proliferation persisted at 1 month after the last allergen exposure. The other parameters and cellular inflammatory response returned to baseline within 1 month after the last allergen challenge. Conclusions: Based on the findings in this study, we conclude that acute allergic airway inflammation, although being initiated from the airways, is able to evoke similar long-term structural alterations in pulmonary vessels as described for bronchi.},
  author       = {Rydell-Törmänen, Kristina and Uller, Lena and Erjefält, Jonas},
  issn         = {1423-0097},
  language     = {eng},
  number       = {3},
  pages        = {251--258},
  publisher    = {Karger},
  series       = {International Archives of Allergy and Immunology1994-01-01+01:00},
  title        = {Allergic Airway Inflammation Initiates Long-Term Vascular Remodeling of the Pulmonary Circulation.},
  url          = {http://dx.doi.org/10.1159/000199721},
  volume       = {149},
  year         = {2009},
}