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Sensitizing capacity and cross-reactivity of phenyl glycidyl ether studied in the guinea-pig maximization test.

Pontén, Ann LU ; Zimerson, Erik LU and Bruze, Magnus LU (2009) In Contact Dermatitis 60(2). p.79-84
Abstract
BACKGROUND: Simultaneous contact allergies to the reactive diluent phenyl glycidyl ether (PGE) and epoxy resins based on diglycidyl ether of bisphenol A (DGEBA) or epoxy resins of the bisphenol F-type have been reported. The latter epoxy resins contain three isomers of diglycidyl ether of bisphenol F (DGEBF). PGE, DGEBA, and DGEBF are chemically similar with respect to the reactive glycidyl group and an aromatic ring, making cross-reactivity one of the possible explanations to simultaneous reactions. AIM: To investigate the sensitizing capacity of PGE and the cross-reactivity of PGE versus the epoxy resin monomers DGEBA and the three DGEBF monomers and vice versa. METHOD: The guinea-pig maximization test. RESULTS: PGE is a strong... (More)
BACKGROUND: Simultaneous contact allergies to the reactive diluent phenyl glycidyl ether (PGE) and epoxy resins based on diglycidyl ether of bisphenol A (DGEBA) or epoxy resins of the bisphenol F-type have been reported. The latter epoxy resins contain three isomers of diglycidyl ether of bisphenol F (DGEBF). PGE, DGEBA, and DGEBF are chemically similar with respect to the reactive glycidyl group and an aromatic ring, making cross-reactivity one of the possible explanations to simultaneous reactions. AIM: To investigate the sensitizing capacity of PGE and the cross-reactivity of PGE versus the epoxy resin monomers DGEBA and the three DGEBF monomers and vice versa. METHOD: The guinea-pig maximization test. RESULTS: PGE is a strong sensitizer. Induction with DGEBA resulted in a statistically significant number of animals reacting to PGE, but when induced with PGE, the animals did not react significantly to DGEBA. CONCLUSIONS: When the results are applied to humans, it can be assumed that patients sensitized primarily to DGEBA react to PGE, but when sensitized exclusively to PGE, they do not react to DGEBA. Both reactive diluents and epoxy resins should be tested when contact allergy to epoxy resin systems are suspected. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
60
issue
2
pages
79 - 84
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000263999100003
  • pmid:19207377
  • scopus:58849117989
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2008.01475.x
language
English
LU publication?
yes
id
fc741d11-16f2-450c-8a0f-16738f663aa4 (old id 1302710)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19207377?dopt=Abstract
date added to LUP
2009-03-05 15:30:49
date last changed
2017-01-01 07:41:07
@article{fc741d11-16f2-450c-8a0f-16738f663aa4,
  abstract     = {BACKGROUND: Simultaneous contact allergies to the reactive diluent phenyl glycidyl ether (PGE) and epoxy resins based on diglycidyl ether of bisphenol A (DGEBA) or epoxy resins of the bisphenol F-type have been reported. The latter epoxy resins contain three isomers of diglycidyl ether of bisphenol F (DGEBF). PGE, DGEBA, and DGEBF are chemically similar with respect to the reactive glycidyl group and an aromatic ring, making cross-reactivity one of the possible explanations to simultaneous reactions. AIM: To investigate the sensitizing capacity of PGE and the cross-reactivity of PGE versus the epoxy resin monomers DGEBA and the three DGEBF monomers and vice versa. METHOD: The guinea-pig maximization test. RESULTS: PGE is a strong sensitizer. Induction with DGEBA resulted in a statistically significant number of animals reacting to PGE, but when induced with PGE, the animals did not react significantly to DGEBA. CONCLUSIONS: When the results are applied to humans, it can be assumed that patients sensitized primarily to DGEBA react to PGE, but when sensitized exclusively to PGE, they do not react to DGEBA. Both reactive diluents and epoxy resins should be tested when contact allergy to epoxy resin systems are suspected.},
  author       = {Pontén, Ann and Zimerson, Erik and Bruze, Magnus},
  issn         = {0105-1873},
  language     = {eng},
  number       = {2},
  pages        = {79--84},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Sensitizing capacity and cross-reactivity of phenyl glycidyl ether studied in the guinea-pig maximization test.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2008.01475.x},
  volume       = {60},
  year         = {2009},
}