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Does vitamin d intake during infancy promote the development of atopic allergy?

Bäck, Ove LU ; Blomquist, Hans K Son; Hernell, Olle and Stenberg, Berndt (2009) In Acta Dermato-Venereologica 89(1). p.28-32
Abstract
The active metabolite of vitamin D, 1,25-(OH)2D3, has immunomodulatory properties in addition to its more established action on bone and calcium metabolism. Recently vitamin D has been proposed as one of several environmental factors responsible for the increase in atopic diseases during the last decades. The objective of this study was to determine whether the estimated dose of dietary vitamin D3 during the first year of life is associated with atopic diseases up to the age of 6 years. In a prospective birth cohort study 123 six-year-old children were investigated for the cumulative incidence of atopic dermatitis, allergic rhinitis or asthma by means of a postal questionnaire. Their vitamin D3 intake during infancy was recorded in a... (More)
The active metabolite of vitamin D, 1,25-(OH)2D3, has immunomodulatory properties in addition to its more established action on bone and calcium metabolism. Recently vitamin D has been proposed as one of several environmental factors responsible for the increase in atopic diseases during the last decades. The objective of this study was to determine whether the estimated dose of dietary vitamin D3 during the first year of life is associated with atopic diseases up to the age of 6 years. In a prospective birth cohort study 123 six-year-old children were investigated for the cumulative incidence of atopic dermatitis, allergic rhinitis or asthma by means of a postal questionnaire. Their vitamin D3 intake during infancy was recorded in a previous study and the relationship between lower or higher vitamin D3 intake and atopic illness later in childhood was assessed. Atopic manifestations were more prevalent in the group with higher intake of vitamin D3. Although small, this study supports previous investigations suggesting a role of vitamin D intake during infancy in the development of atopic allergy later in childhood. If these findings are confirmed in prospective controlled clinical trials, prevention through modified vitamin D3 supplementation in infancy could be discussed to reduce the burden of atopic illnesses. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
89
issue
1
pages
28 - 32
publisher
Medical Journals Limited
external identifiers
  • wos:000262563900006
  • pmid:19197538
  • scopus:58549096744
ISSN
1651-2057
DOI
10.2340/00015555-0541
language
English
LU publication?
yes
id
9a4e6ba6-b536-45fd-a67f-8ab5ce22e1dd (old id 1302823)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19197538?dopt=Abstract
date added to LUP
2009-03-02 15:49:27
date last changed
2017-06-18 04:43:33
@article{9a4e6ba6-b536-45fd-a67f-8ab5ce22e1dd,
  abstract     = {The active metabolite of vitamin D, 1,25-(OH)2D3, has immunomodulatory properties in addition to its more established action on bone and calcium metabolism. Recently vitamin D has been proposed as one of several environmental factors responsible for the increase in atopic diseases during the last decades. The objective of this study was to determine whether the estimated dose of dietary vitamin D3 during the first year of life is associated with atopic diseases up to the age of 6 years. In a prospective birth cohort study 123 six-year-old children were investigated for the cumulative incidence of atopic dermatitis, allergic rhinitis or asthma by means of a postal questionnaire. Their vitamin D3 intake during infancy was recorded in a previous study and the relationship between lower or higher vitamin D3 intake and atopic illness later in childhood was assessed. Atopic manifestations were more prevalent in the group with higher intake of vitamin D3. Although small, this study supports previous investigations suggesting a role of vitamin D intake during infancy in the development of atopic allergy later in childhood. If these findings are confirmed in prospective controlled clinical trials, prevention through modified vitamin D3 supplementation in infancy could be discussed to reduce the burden of atopic illnesses.},
  author       = {Bäck, Ove and Blomquist, Hans K Son and Hernell, Olle and Stenberg, Berndt},
  issn         = {1651-2057},
  language     = {eng},
  number       = {1},
  pages        = {28--32},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Does vitamin d intake during infancy promote the development of atopic allergy?},
  url          = {http://dx.doi.org/10.2340/00015555-0541},
  volume       = {89},
  year         = {2009},
}