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Metabolic effects of furaldehydes and impacts on biotechnological processes.

Almeida, Joao LU ; Wiman, Magnus LU ; Gorwa-Grauslund, Marie-Francoise LU ; Gorsich, Steven and Lidén, Gunnar LU (2009) In Applied Microbiology and Biotechnology 82(4). p.625-638
Abstract
There is a growing awareness that lignocellulose will be a major raw material for production of both fuel and chemicals in the coming decades-most likely through various fermentation routes. Considerable attention has been given to the problem of finding efficient means of separating the major constituents in lignocellulose (i.e., lignin, hemicellulose, and cellulose) and to efficiently hydrolyze the carbohydrate parts into sugars. In these processes, by-products will inevitably form to some extent, and these will have to be dealt with in the ensuing microbial processes. One group of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes-most importantly 5-hydroxymethyl-2-furaldehyde-are the... (More)
There is a growing awareness that lignocellulose will be a major raw material for production of both fuel and chemicals in the coming decades-most likely through various fermentation routes. Considerable attention has been given to the problem of finding efficient means of separating the major constituents in lignocellulose (i.e., lignin, hemicellulose, and cellulose) and to efficiently hydrolyze the carbohydrate parts into sugars. In these processes, by-products will inevitably form to some extent, and these will have to be dealt with in the ensuing microbial processes. One group of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes-most importantly 5-hydroxymethyl-2-furaldehyde-are the dominant inhibitory compounds found in lignocellulosic hydrolyzates. The furaldehydes are known to have biological effects and act as inhibitors in fermentation processes. The effects of these compounds will therefore have to be considered in the design of biotechnological processes using lignocellulose. In this short review, we take a look at known metabolic effects, as well as strategies to overcome problems in biotechnological applications caused by furaldehydes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Microbiology and Biotechnology
volume
82
issue
4
pages
625 - 638
publisher
Springer
external identifiers
  • wos:000263777400003
  • pmid:19184597
  • scopus:61449172838
ISSN
1432-0614
DOI
10.1007/s00253-009-1875-1
language
English
LU publication?
yes
id
8362bc7b-a32f-4807-bac6-2bcb52896c6c (old id 1302991)
date added to LUP
2009-03-10 16:06:19
date last changed
2017-12-10 04:21:50
@article{8362bc7b-a32f-4807-bac6-2bcb52896c6c,
  abstract     = {There is a growing awareness that lignocellulose will be a major raw material for production of both fuel and chemicals in the coming decades-most likely through various fermentation routes. Considerable attention has been given to the problem of finding efficient means of separating the major constituents in lignocellulose (i.e., lignin, hemicellulose, and cellulose) and to efficiently hydrolyze the carbohydrate parts into sugars. In these processes, by-products will inevitably form to some extent, and these will have to be dealt with in the ensuing microbial processes. One group of compounds in this category is the furaldehydes. 2-Furaldehyde (furfural) and substituted 2-furaldehydes-most importantly 5-hydroxymethyl-2-furaldehyde-are the dominant inhibitory compounds found in lignocellulosic hydrolyzates. The furaldehydes are known to have biological effects and act as inhibitors in fermentation processes. The effects of these compounds will therefore have to be considered in the design of biotechnological processes using lignocellulose. In this short review, we take a look at known metabolic effects, as well as strategies to overcome problems in biotechnological applications caused by furaldehydes.},
  author       = {Almeida, Joao and Wiman, Magnus and Gorwa-Grauslund, Marie-Francoise and Gorsich, Steven and Lidén, Gunnar},
  issn         = {1432-0614},
  language     = {eng},
  number       = {4},
  pages        = {625--638},
  publisher    = {Springer},
  series       = {Applied Microbiology and Biotechnology},
  title        = {Metabolic effects of furaldehydes and impacts on biotechnological processes.},
  url          = {http://dx.doi.org/10.1007/s00253-009-1875-1},
  volume       = {82},
  year         = {2009},
}