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Plasma homocysteine and vascular disease in elderly patients with mental illness

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2008) In Clinical Chemistry and Laboratory Medicine 46(11). p.1556-1561
Abstract
Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness compared to control subjects. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors, such as age and genetics. In this review, we summarize the findings of our investigations of vascular disease and plasma tHcy level in elderly patients with mental illness. Elevated plasma tHcy concentration in elderly patients with mental illness was mainly associated with the presence... (More)
Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness compared to control subjects. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors, such as age and genetics. In this review, we summarize the findings of our investigations of vascular disease and plasma tHcy level in elderly patients with mental illness. Elevated plasma tHcy concentration in elderly patients with mental illness was mainly associated with the presence of vascular disease and was not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, serum N-terminal pro-brain natriuretic peptide, and serum C-reactive protein. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular disease, Alzheimer's disease, homocysteine, mental illness, vascular dementia
in
Clinical Chemistry and Laboratory Medicine
volume
46
issue
11
pages
1556 - 1561
publisher
De Gruyter
external identifiers
  • wos:000261386100011
  • pmid:18842107
  • scopus:56549111885
ISSN
1434-6621
DOI
10.1515/CCLM.2008.301
language
English
LU publication?
yes
id
be8406d4-704d-434c-9898-9bdca900c591 (old id 1305692)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18842107?dopt=Abstract
date added to LUP
2009-03-23 12:28:02
date last changed
2017-01-01 05:18:42
@article{be8406d4-704d-434c-9898-9bdca900c591,
  abstract     = {Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness compared to control subjects. There are many different determinants of plasma tHcy concentration, including the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors, such as age and genetics. In this review, we summarize the findings of our investigations of vascular disease and plasma tHcy level in elderly patients with mental illness. Elevated plasma tHcy concentration in elderly patients with mental illness was mainly associated with the presence of vascular disease and was not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, serum N-terminal pro-brain natriuretic peptide, and serum C-reactive protein.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1434-6621},
  keyword      = {vascular disease,Alzheimer's disease,homocysteine,mental illness,vascular dementia},
  language     = {eng},
  number       = {11},
  pages        = {1556--1561},
  publisher    = {De Gruyter},
  series       = {Clinical Chemistry and Laboratory Medicine},
  title        = {Plasma homocysteine and vascular disease in elderly patients with mental illness},
  url          = {http://dx.doi.org/10.1515/CCLM.2008.301},
  volume       = {46},
  year         = {2008},
}