Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients.
(2004) In Diabetes Care 27(12). p.2936-2941- Abstract
- OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.
RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index >1.64 SD and E/I ratio <−1.64 SD were considered... (More) - OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.
RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index >1.64 SD and E/I ratio <−1.64 SD were considered abnormal.
RESULTS—VAC index was abnormal in 40% with type 1 and 41% with type 2 diabetes, whereas the E/I ratio was abnormal in 42% with type 1 and 65% with type 2 diabetes. There was a clear association between VAC index and E/I ratio among type 1 (rs = 0.525; P = 0.0002) but not among type 2 (rs = 0.10) diabetic patients. Among type 2 diabetic patients, the degree of dysfunction was most severe regarding parasympathetic function (P = 0.0167).
CONCLUSIONS—Sympathetic and parasympathetic neuropathy were frequent in both type 1 and type 2 diabetic patients. However, there was a difference between the two types of diabetes. Sympathetic and parasympathetic nerve functions correlated in type 1 but not in type 2 diabetic patients. The explanation for this discrepancy might be that parasympathetic nerve function was most severely affected among type 2 diabetic patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/130662
- author
- Freccero, Carolin LU ; Svensson, Henry LU ; Wollmer, Per LU and Sundkvist, Göran LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 27
- issue
- 12
- pages
- 2936 - 2941
- publisher
- American Diabetes Association
- external identifiers
-
- wos:000225331900027
- pmid:15562210
- scopus:9444260371
- ISSN
- 1935-5548
- DOI
- 10.2337/diacare.27.12.2936
- language
- English
- LU publication?
- yes
- id
- 9304e979-b639-4cf3-aa7c-d03db535349d (old id 130662)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15562210&dopt=Abstract
- date added to LUP
- 2016-04-01 16:08:01
- date last changed
- 2023-09-04 12:57:39
@article{9304e979-b639-4cf3-aa7c-d03db535349d, abstract = {{OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.<br/><br> <br/><br> RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index >1.64 SD and E/I ratio <−1.64 SD were considered abnormal.<br/><br> <br/><br> RESULTS—VAC index was abnormal in 40% with type 1 and 41% with type 2 diabetes, whereas the E/I ratio was abnormal in 42% with type 1 and 65% with type 2 diabetes. There was a clear association between VAC index and E/I ratio among type 1 (rs = 0.525; P = 0.0002) but not among type 2 (rs = 0.10) diabetic patients. Among type 2 diabetic patients, the degree of dysfunction was most severe regarding parasympathetic function (P = 0.0167).<br/><br> <br/><br> CONCLUSIONS—Sympathetic and parasympathetic neuropathy were frequent in both type 1 and type 2 diabetic patients. However, there was a difference between the two types of diabetes. Sympathetic and parasympathetic nerve functions correlated in type 1 but not in type 2 diabetic patients. The explanation for this discrepancy might be that parasympathetic nerve function was most severely affected among type 2 diabetic patients.}}, author = {{Freccero, Carolin and Svensson, Henry and Wollmer, Per and Sundkvist, Göran}}, issn = {{1935-5548}}, language = {{eng}}, number = {{12}}, pages = {{2936--2941}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients.}}, url = {{http://dx.doi.org/10.2337/diacare.27.12.2936}}, doi = {{10.2337/diacare.27.12.2936}}, volume = {{27}}, year = {{2004}}, }