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Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients.

Freccero, Carolin LU ; Svensson, Henry LU ; Wollmer, Per LU and Sundkvist, Göran LU (2004) In Diabetes Care 27(12). p.2936-2941
Abstract
OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.



RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index >1.64 SD and E/I ratio <−1.64 SD were considered... (More)
OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.



RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index >1.64 SD and E/I ratio <−1.64 SD were considered abnormal.



RESULTS—VAC index was abnormal in 40% with type 1 and 41% with type 2 diabetes, whereas the E/I ratio was abnormal in 42% with type 1 and 65% with type 2 diabetes. There was a clear association between VAC index and E/I ratio among type 1 (rs = 0.525; P = 0.0002) but not among type 2 (rs = 0.10) diabetic patients. Among type 2 diabetic patients, the degree of dysfunction was most severe regarding parasympathetic function (P = 0.0167).



CONCLUSIONS—Sympathetic and parasympathetic neuropathy were frequent in both type 1 and type 2 diabetic patients. However, there was a difference between the two types of diabetes. Sympathetic and parasympathetic nerve functions correlated in type 1 but not in type 2 diabetic patients. The explanation for this discrepancy might be that parasympathetic nerve function was most severely affected among type 2 diabetic patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
27
issue
12
pages
2936 - 2941
publisher
American Diabetes Association
external identifiers
  • wos:000225331900027
  • pmid:15562210
  • scopus:9444260371
ISSN
1935-5548
DOI
10.2337/diacare.27.12.2936
language
English
LU publication?
yes
id
9304e979-b639-4cf3-aa7c-d03db535349d (old id 130662)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15562210&dopt=Abstract
date added to LUP
2007-07-19 11:42:06
date last changed
2017-04-09 04:17:37
@article{9304e979-b639-4cf3-aa7c-d03db535349d,
  abstract     = {OBJECTIVE—The aim of this study was to evaluate the frequency of sympathetic versus parasympathetic neuropathy among type 1 and type 2 diabetic patients.<br/><br>
<br/><br>
RESEARCH DESIGN AND METHODS—There were 43 patients with type 1 and 17 with type 2 diabetes who were investigated. Sympathetic nerve function was assessed by measurement of the vasoconstriction (VAC) index by laser Doppler perfusion imaging of a locally heated finger followed by indirect cooling. Parasympathetic nerve function was assessed by R-R interval variation during deep breathing as measured by the expiration/inspiration (E/I) ratio. Results were expressed as age-corrected z scores in SD; VAC index &gt;1.64 SD and E/I ratio &lt;−1.64 SD were considered abnormal.<br/><br>
<br/><br>
RESULTS—VAC index was abnormal in 40% with type 1 and 41% with type 2 diabetes, whereas the E/I ratio was abnormal in 42% with type 1 and 65% with type 2 diabetes. There was a clear association between VAC index and E/I ratio among type 1 (rs = 0.525; P = 0.0002) but not among type 2 (rs = 0.10) diabetic patients. Among type 2 diabetic patients, the degree of dysfunction was most severe regarding parasympathetic function (P = 0.0167).<br/><br>
<br/><br>
CONCLUSIONS—Sympathetic and parasympathetic neuropathy were frequent in both type 1 and type 2 diabetic patients. However, there was a difference between the two types of diabetes. Sympathetic and parasympathetic nerve functions correlated in type 1 but not in type 2 diabetic patients. The explanation for this discrepancy might be that parasympathetic nerve function was most severely affected among type 2 diabetic patients.},
  author       = {Freccero, Carolin and Svensson, Henry and Wollmer, Per and Sundkvist, Göran},
  issn         = {1935-5548},
  language     = {eng},
  number       = {12},
  pages        = {2936--2941},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients.},
  url          = {http://dx.doi.org/10.2337/diacare.27.12.2936},
  volume       = {27},
  year         = {2004},
}