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The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications

Axelsson, Anders LU and Marucci, Mariagrazia LU (2008) In Optics and Lasers in Engineering 46(12). p.865-876
Abstract
In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can... (More)
In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can be quantified, and it is also possible to discriminate between permeable and semi-permeable membranes. In this review the influence of temperature, natural convection and light deflection on the accuracy of the diffusion measurements is also discussed. (c) 2008 Elsevier Ltd. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Pharmaceutical, Protein, Membrane, Gel, Diffusion, ESPI, Holographic laser interferometry, Bioseparation, Osmosis
in
Optics and Lasers in Engineering
volume
46
issue
12
pages
865 - 876
publisher
Elsevier
external identifiers
  • wos:000260972500003
  • scopus:53249098883
ISSN
0143-8166
DOI
10.1016/j.optlaseng.2008.03.017
language
English
LU publication?
yes
id
9f80a483-b795-419d-b725-3d5e1c6d1fc1 (old id 1308623)
date added to LUP
2009-03-19 10:58:27
date last changed
2017-07-23 03:48:24
@article{9f80a483-b795-419d-b725-3d5e1c6d1fc1,
  abstract     = {In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can be quantified, and it is also possible to discriminate between permeable and semi-permeable membranes. In this review the influence of temperature, natural convection and light deflection on the accuracy of the diffusion measurements is also discussed. (c) 2008 Elsevier Ltd. All rights reserved.},
  author       = {Axelsson, Anders and Marucci, Mariagrazia},
  issn         = {0143-8166},
  keyword      = {Pharmaceutical,Protein,Membrane,Gel,Diffusion,ESPI,Holographic laser interferometry,Bioseparation,Osmosis},
  language     = {eng},
  number       = {12},
  pages        = {865--876},
  publisher    = {Elsevier},
  series       = {Optics and Lasers in Engineering},
  title        = {The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications},
  url          = {http://dx.doi.org/10.1016/j.optlaseng.2008.03.017},
  volume       = {46},
  year         = {2008},
}