The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications
(2008) In Optics and Lasers in Engineering 46(12). p.865-876- Abstract
- In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can... (More)
- In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can be quantified, and it is also possible to discriminate between permeable and semi-permeable membranes. In this review the influence of temperature, natural convection and light deflection on the accuracy of the diffusion measurements is also discussed. (c) 2008 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1308623
- author
- Axelsson, Anders LU and Marucci, Mariagrazia LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pharmaceutical, Protein, Membrane, Gel, Diffusion, ESPI, Holographic laser interferometry, Bioseparation, Osmosis
- in
- Optics and Lasers in Engineering
- volume
- 46
- issue
- 12
- pages
- 865 - 876
- publisher
- Elsevier
- external identifiers
-
- wos:000260972500003
- scopus:53249098883
- ISSN
- 0143-8166
- DOI
- 10.1016/j.optlaseng.2008.03.017
- language
- English
- LU publication?
- yes
- id
- 9f80a483-b795-419d-b725-3d5e1c6d1fc1 (old id 1308623)
- date added to LUP
- 2016-04-01 12:11:14
- date last changed
- 2023-11-11 16:01:34
@article{9f80a483-b795-419d-b725-3d5e1c6d1fc1,
abstract = {{In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can be quantified, and it is also possible to discriminate between permeable and semi-permeable membranes. In this review the influence of temperature, natural convection and light deflection on the accuracy of the diffusion measurements is also discussed. (c) 2008 Elsevier Ltd. All rights reserved.}},
author = {{Axelsson, Anders and Marucci, Mariagrazia}},
issn = {{0143-8166}},
keywords = {{Pharmaceutical; Protein; Membrane; Gel; Diffusion; ESPI; Holographic laser interferometry; Bioseparation; Osmosis}},
language = {{eng}},
number = {{12}},
pages = {{865--876}},
publisher = {{Elsevier}},
series = {{Optics and Lasers in Engineering}},
title = {{The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications}},
url = {{http://dx.doi.org/10.1016/j.optlaseng.2008.03.017}},
doi = {{10.1016/j.optlaseng.2008.03.017}},
volume = {{46}},
year = {{2008}},
}