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Geographic Origin as a Determinant of Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation. The Cardiovascular Risk in Young Finns Study.

Juonala, Markus; Viikari, Jorma S A; Kähönen, Mika; Taittonen, Leena; Rönnemaa, Tapani; Laitinen, Tomi; Mikkilä, Vera; Mäki-Torkko, Noora; Räsänen, Leena and Åkerblom, Hans K, et al. (2005) In Arteriosclerosis, Thrombosis and Vascular Biology 25(2). p.392-398
Abstract
Objective - People living in eastern Finland have approximate to 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns. Methods and Results - As part of a longitudinal follow-up study, we measured carotid intima-media thickness (IMT) in 2264 and brachial flow-mediated dilation (FMD) in 2109 white adults, aged 24 to 39 years. Subjects from eastern Finland had greater IMT and lower FMD compared with western subjects. These differences accentuated when the subjects' family origin ( grandparents' birthplace) was taken into account and remained significant... (More)
Objective - People living in eastern Finland have approximate to 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns. Methods and Results - As part of a longitudinal follow-up study, we measured carotid intima-media thickness (IMT) in 2264 and brachial flow-mediated dilation (FMD) in 2109 white adults, aged 24 to 39 years. Subjects from eastern Finland had greater IMT and lower FMD compared with western subjects. These differences accentuated when the subjects' family origin ( grandparents' birthplace) was taken into account and remained significant after adjusting for several environmental factors. Among subjects with all grandparents born in eastern or western Finland, IMTs were ( mean +/- SEM) 0.592 +/- 0.003 versus 0.565 +/- 0.005 mm ( P < 0.0001), respectively. The corresponding FMD values were 7.61 +/- 0.15% versus 8.75 +/- 0.26%; P < 0.01. The number of grandparents born in eastern Finland was directly related to IMT ( P < 0.0001) and inversely to FMD ( P < 0.05). Conclusions - Young adults originating from eastern Finland have greater carotid IMT and lower brachial FMD than western Finns. Consistent with a hereditable component predisposing to or protecting from atherosclerosis, these differences accentuated when subjects' family origin was taken into account. (Less)
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publication status
published
subject
keywords
flow-mediated dilatation, intima-media thickness, atherosclerosis
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
25
issue
2
pages
392 - 398
publisher
American Heart Association
external identifiers
  • pmid:15539623
  • wos:000226594000023
  • scopus:19944432870
ISSN
1524-4636
DOI
10.1161/01.ATV.0000150042.43866.7f
language
English
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yes
id
723c8d9c-2c88-4730-9efb-fe2a8233cf96 (old id 130875)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15539623&dopt=Abstract
date added to LUP
2007-07-19 13:42:44
date last changed
2017-08-27 04:16:15
@article{723c8d9c-2c88-4730-9efb-fe2a8233cf96,
  abstract     = {Objective - People living in eastern Finland have approximate to 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns. Methods and Results - As part of a longitudinal follow-up study, we measured carotid intima-media thickness (IMT) in 2264 and brachial flow-mediated dilation (FMD) in 2109 white adults, aged 24 to 39 years. Subjects from eastern Finland had greater IMT and lower FMD compared with western subjects. These differences accentuated when the subjects' family origin ( grandparents' birthplace) was taken into account and remained significant after adjusting for several environmental factors. Among subjects with all grandparents born in eastern or western Finland, IMTs were ( mean +/- SEM) 0.592 +/- 0.003 versus 0.565 +/- 0.005 mm ( P &lt; 0.0001), respectively. The corresponding FMD values were 7.61 +/- 0.15% versus 8.75 +/- 0.26%; P &lt; 0.01. The number of grandparents born in eastern Finland was directly related to IMT ( P &lt; 0.0001) and inversely to FMD ( P &lt; 0.05). Conclusions - Young adults originating from eastern Finland have greater carotid IMT and lower brachial FMD than western Finns. Consistent with a hereditable component predisposing to or protecting from atherosclerosis, these differences accentuated when subjects' family origin was taken into account.},
  author       = {Juonala, Markus and Viikari, Jorma S A and Kähönen, Mika and Taittonen, Leena and Rönnemaa, Tapani and Laitinen, Tomi and Mikkilä, Vera and Mäki-Torkko, Noora and Räsänen, Leena and Åkerblom, Hans K and Pesonen, Erkki and Raitakari, Olli T},
  issn         = {1524-4636},
  keyword      = {flow-mediated dilatation,intima-media thickness,atherosclerosis},
  language     = {eng},
  number       = {2},
  pages        = {392--398},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Geographic Origin as a Determinant of Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation. The Cardiovascular Risk in Young Finns Study.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000150042.43866.7f},
  volume       = {25},
  year         = {2005},
}