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Acquisition of anti-phosphatidylserine IgM and IgG antibodies by infants and their mothers over time in Uganda

Tijani, Muyideen Kolapo LU ; Saleh, Bandar Hassan LU ; Lugaajju, Allan LU ; Danielsson, Lena LU and Persson, Kristina E.M. LU (2024) In Frontiers in Immunology 15.
Abstract

Background: Production of anti-phosphatidylserine (anti-PS) antibodies has been associated with malaria and can aggravate pathology. How these autoantibodies develop during early childhood in a malaria context is not known. We examined levels of anti-PS IgG and IgM antibodies in a longitudinal cohort of mother-baby pairs during birth, in the infants at 2.5, 6 months, and in mothers and their babies at 9 months postpartum. Results: There was no difference between levels of anti-PS IgG in cord blood and the mothers’ peripheral blood at birth. However, anti-PS IgM levels were significantly higher in the mothers compared to the infants’ cord blood, and IgM levels were steadily increasing during the first 9 months of the infants’ life. In... (More)

Background: Production of anti-phosphatidylserine (anti-PS) antibodies has been associated with malaria and can aggravate pathology. How these autoantibodies develop during early childhood in a malaria context is not known. We examined levels of anti-PS IgG and IgM antibodies in a longitudinal cohort of mother-baby pairs during birth, in the infants at 2.5, 6 months, and in mothers and their babies at 9 months postpartum. Results: There was no difference between levels of anti-PS IgG in cord blood and the mothers’ peripheral blood at birth. However, anti-PS IgM levels were significantly higher in the mothers compared to the infants’ cord blood, and IgM levels were steadily increasing during the first 9 months of the infants’ life. In infants that had the highest anti-PS IgM levels at birth, there was a decline until 6 months with a rise at 9 months. Infants that possessed high anti-PS IgG at birth also exhibited a progressive decline in levels. When anti-PS were correlated to different fractions of B-cells, there were several correlations with P. falciparum specific atypical B cells both at birth and at 2.5 months for the infants, especially for anti-PS IgM. Anti-PS also correlated strongly to C1q-fixing antibodies at birth. Conclusion: These results show that anti-PS IgG acquired by mothers could be transferred transplacentally and that IgM antibodies targeting PS are acquired during the first year of life. These results have increased the knowledge about autoimmune responses associated with infections in early life and is critical for a comprehensive understanding of malaria vaccine functionality in endemic areas.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IgG, IgM, infants, malaria, phosphatidylserine, Plasmodium falciparum
in
Frontiers in Immunology
volume
15
article number
1416669
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85200729006
  • pmid:39131160
ISSN
1664-3224
DOI
10.3389/fimmu.2024.1416669
language
English
LU publication?
yes
additional info
Publisher Copyright: Copyright © 2024 Tijani, Saleh, Lugaajju, Danielsson and Persson.
id
130a7ec9-736a-4247-b31d-2c2e82082dbe
date added to LUP
2024-10-17 11:58:42
date last changed
2025-07-25 12:30:20
@article{130a7ec9-736a-4247-b31d-2c2e82082dbe,
  abstract     = {{<p>Background: Production of anti-phosphatidylserine (anti-PS) antibodies has been associated with malaria and can aggravate pathology. How these autoantibodies develop during early childhood in a malaria context is not known. We examined levels of anti-PS IgG and IgM antibodies in a longitudinal cohort of mother-baby pairs during birth, in the infants at 2.5, 6 months, and in mothers and their babies at 9 months postpartum. Results: There was no difference between levels of anti-PS IgG in cord blood and the mothers’ peripheral blood at birth. However, anti-PS IgM levels were significantly higher in the mothers compared to the infants’ cord blood, and IgM levels were steadily increasing during the first 9 months of the infants’ life. In infants that had the highest anti-PS IgM levels at birth, there was a decline until 6 months with a rise at 9 months. Infants that possessed high anti-PS IgG at birth also exhibited a progressive decline in levels. When anti-PS were correlated to different fractions of B-cells, there were several correlations with P. falciparum specific atypical B cells both at birth and at 2.5 months for the infants, especially for anti-PS IgM. Anti-PS also correlated strongly to C1q-fixing antibodies at birth. Conclusion: These results show that anti-PS IgG acquired by mothers could be transferred transplacentally and that IgM antibodies targeting PS are acquired during the first year of life. These results have increased the knowledge about autoimmune responses associated with infections in early life and is critical for a comprehensive understanding of malaria vaccine functionality in endemic areas.</p>}},
  author       = {{Tijani, Muyideen Kolapo and Saleh, Bandar Hassan and Lugaajju, Allan and Danielsson, Lena and Persson, Kristina E.M.}},
  issn         = {{1664-3224}},
  keywords     = {{IgG; IgM; infants; malaria; phosphatidylserine; Plasmodium falciparum}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Immunology}},
  title        = {{Acquisition of anti-phosphatidylserine IgM and IgG antibodies by infants and their mothers over time in Uganda}},
  url          = {{http://dx.doi.org/10.3389/fimmu.2024.1416669}},
  doi          = {{10.3389/fimmu.2024.1416669}},
  volume       = {{15}},
  year         = {{2024}},
}