Advanced

Immunomodulation of Atherosclerosis. Implications for Vaccine Development.

Nilsson, Jan LU ; Hansson, Göran K and Shah, Prediman K (2005) In Arteriosclerosis, Thrombosis and Vascular Biology 25(1). p.18-28
Abstract
A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified.... (More)
A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified. These immune responses may be modulated by presenting the antigens together with different types of adjuvants as well as through the route of administration. In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
heat shock proteins, immunity, atherosclerosis, vaccine, lipoproteins
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
25
issue
1
pages
18 - 28
publisher
American Heart Association
external identifiers
  • pmid:15514204
  • wos:000226065900007
  • scopus:11144224296
ISSN
1524-4636
DOI
10.1161/01.ATV.0000149142.42590.a2
language
English
LU publication?
yes
id
bd3fe928-a492-4969-bc88-3ee755030d7a (old id 131047)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15514204&dopt=Abstract
date added to LUP
2007-07-26 15:33:28
date last changed
2017-10-01 03:46:25
@article{bd3fe928-a492-4969-bc88-3ee755030d7a,
  abstract     = {A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified. These immune responses may be modulated by presenting the antigens together with different types of adjuvants as well as through the route of administration. In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis.},
  author       = {Nilsson, Jan and Hansson, Göran K and Shah, Prediman K},
  issn         = {1524-4636},
  keyword      = {heat shock proteins,immunity,atherosclerosis,vaccine,lipoproteins},
  language     = {eng},
  number       = {1},
  pages        = {18--28},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Immunomodulation of Atherosclerosis. Implications for Vaccine Development.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000149142.42590.a2},
  volume       = {25},
  year         = {2005},
}