Immunomodulation of Atherosclerosis. Implications for Vaccine Development.
(2005) In Arteriosclerosis, Thrombosis and Vascular Biology 25(1). p.18-28- Abstract
- A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified.... (More)
- A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified. These immune responses may be modulated by presenting the antigens together with different types of adjuvants as well as through the route of administration. In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/131047
- author
- Nilsson, Jan LU ; Hansson, Göran K and Shah, Prediman K
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- heat shock proteins, immunity, atherosclerosis, vaccine, lipoproteins
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 25
- issue
- 1
- pages
- 18 - 28
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:15514204
- wos:000226065900007
- scopus:11144224296
- ISSN
- 1524-4636
- DOI
- 10.1161/01.ATV.0000149142.42590.a2
- language
- English
- LU publication?
- yes
- id
- bd3fe928-a492-4969-bc88-3ee755030d7a (old id 131047)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15514204&dopt=Abstract
- date added to LUP
- 2016-04-01 12:03:10
- date last changed
- 2022-04-28 23:56:05
@article{bd3fe928-a492-4969-bc88-3ee755030d7a,
abstract = {{A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammation. These observations suggest the possibility that selective suppression of proatherogenic immune responses or selective activation of antiatherogenic immune responses may provide new approaches for atherosclerosis prevention and treatment. Several antigens activating immune responses affecting development of atherosclerosis have been identified. These immune responses may be modulated by presenting the antigens together with different types of adjuvants as well as through the route of administration. In this review, we summarize recent experimental studies using immunomodulatory approaches for treatment of atherosclerosis.}},
author = {{Nilsson, Jan and Hansson, Göran K and Shah, Prediman K}},
issn = {{1524-4636}},
keywords = {{heat shock proteins; immunity; atherosclerosis; vaccine; lipoproteins}},
language = {{eng}},
number = {{1}},
pages = {{18--28}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
title = {{Immunomodulation of Atherosclerosis. Implications for Vaccine Development.}},
url = {{http://dx.doi.org/10.1161/01.ATV.0000149142.42590.a2}},
doi = {{10.1161/01.ATV.0000149142.42590.a2}},
volume = {{25}},
year = {{2005}},
}