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Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia

Johansson, Bertil LU ; Mertens, Fredrik LU and Mitelman, Felix LU (2004) In Annals of Medicine 36(7). p.492-503
Abstract

Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closely with specific morphologic, immunophenotypic, and clinical parameters. Thus, karyotypic investigations are now routinely performed for diagnostic and prognostic purposes in ALL, with the chromosomal abnormalities/cytogenetic patterns playing a major role for proper risk assessment and choice of treatment. At the same time, the cytogenetic analyses have resulted in the identification of more than 70 different genes, located... (More)

Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closely with specific morphologic, immunophenotypic, and clinical parameters. Thus, karyotypic investigations are now routinely performed for diagnostic and prognostic purposes in ALL, with the chromosomal abnormalities/cytogenetic patterns playing a major role for proper risk assessment and choice of treatment. At the same time, the cytogenetic analyses have resulted in the identification of more than 70 different genes, located at the breakpoints of ALL-associated structural chromosomal abnormalities, that are causally implicated in the leukemogenic process. Hence, the genetic studies have also improved our understanding of the mechanisms of leukemogenesis. However, the almost staggering amount of cytogenetic information presently available has made it increasingly difficult to obtain a general overview of the clinical and biological importance of karyotypic patterns in ALL. Here, we summarize and review the cytogenetic features of childhood and adult ALL, with emphasis on their molecular genetic consequences and their clinical impact.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Adult, Child, Chromosome Aberrations, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Annals of Medicine
volume
36
issue
7
pages
12 pages
publisher
Informa Healthcare
external identifiers
  • pmid:15513300
  • wos:000225102500002
  • scopus:8544247921
ISSN
1365-2060
DOI
10.1080/07853890410018808
language
English
LU publication?
yes
id
41e5e312-5bc0-412b-a99c-e64efb13b974 (old id 131089)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15513300&dopt=Abstract
date added to LUP
2007-07-07 09:59:11
date last changed
2017-04-02 03:22:21
@article{41e5e312-5bc0-412b-a99c-e64efb13b974,
  abstract     = {<p>Among the approximately 7,000 cytogenetically abnormal childhood and adult B- and T-lineage acute lymphoblastic leukemias (ALL) published to date, numerous recurring chromosomal aberrations and abnormality patterns have been identified, and it has been clearly shown that the cytogenetic features often correlate closely with specific morphologic, immunophenotypic, and clinical parameters. Thus, karyotypic investigations are now routinely performed for diagnostic and prognostic purposes in ALL, with the chromosomal abnormalities/cytogenetic patterns playing a major role for proper risk assessment and choice of treatment. At the same time, the cytogenetic analyses have resulted in the identification of more than 70 different genes, located at the breakpoints of ALL-associated structural chromosomal abnormalities, that are causally implicated in the leukemogenic process. Hence, the genetic studies have also improved our understanding of the mechanisms of leukemogenesis. However, the almost staggering amount of cytogenetic information presently available has made it increasingly difficult to obtain a general overview of the clinical and biological importance of karyotypic patterns in ALL. Here, we summarize and review the cytogenetic features of childhood and adult ALL, with emphasis on their molecular genetic consequences and their clinical impact.</p>},
  author       = {Johansson, Bertil and Mertens, Fredrik and Mitelman, Felix},
  issn         = {1365-2060},
  keyword      = {Adult,Child,Chromosome Aberrations,Humans,Precursor Cell Lymphoblastic Leukemia-Lymphoma,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {7},
  pages        = {492--503},
  publisher    = {Informa Healthcare},
  series       = {Annals of Medicine},
  title        = {Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1080/07853890410018808},
  volume       = {36},
  year         = {2004},
}