Advanced

Virulence properties of asymptomatic bacteriuria Escherichia coli

Mabbett, Amanda N.; Ulett, Glen C.; Watts, Rebecca E.; Tree, Jai J.; Totsika, Makrina; Ong, Cheryl-lynn Y.; Wood, Jacqueline M.; Monaghan, Wayne; Looke, David F. and Nimmo, Graeme R., et al. (2009) In International Journal of Medical Microbiology 299(1). p.53-63
Abstract
In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to... (More)
In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E coli evade immune detection after the establishment of bacteriuria. (C) 2008 Elsevier GmbH. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Proinflammatory cytokines, Host response, infection, Urinary tract, Fimbriae, Asymptomatic bacteriuria, Escherichia coli
in
International Journal of Medical Microbiology
volume
299
issue
1
pages
53 - 63
publisher
Elsevier
external identifiers
  • wos:000263074400006
  • scopus:56949098158
ISSN
1618-0607
DOI
10.1016/j.ijmm.2008.06.003
language
English
LU publication?
yes
id
de9ebdac-5cc9-4029-996e-0a1e19f3ba20 (old id 1311443)
date added to LUP
2009-03-18 08:50:45
date last changed
2017-12-10 03:42:40
@article{de9ebdac-5cc9-4029-996e-0a1e19f3ba20,
  abstract     = {In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E coli evade immune detection after the establishment of bacteriuria. (C) 2008 Elsevier GmbH. All rights reserved.},
  author       = {Mabbett, Amanda N. and Ulett, Glen C. and Watts, Rebecca E. and Tree, Jai J. and Totsika, Makrina and Ong, Cheryl-lynn Y. and Wood, Jacqueline M. and Monaghan, Wayne and Looke, David F. and Nimmo, Graeme R. and Svanborg, Catharina and Schembri, Mark A.},
  issn         = {1618-0607},
  keyword      = {Proinflammatory cytokines,Host response,infection,Urinary tract,Fimbriae,Asymptomatic bacteriuria,Escherichia coli},
  language     = {eng},
  number       = {1},
  pages        = {53--63},
  publisher    = {Elsevier},
  series       = {International Journal of Medical Microbiology},
  title        = {Virulence properties of asymptomatic bacteriuria Escherichia coli},
  url          = {http://dx.doi.org/10.1016/j.ijmm.2008.06.003},
  volume       = {299},
  year         = {2009},
}