Virulence properties of asymptomatic bacteriuria Escherichia coli
(2009) In International Journal of Medical Microbiology 299(1). p.53-63- Abstract
- In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to... (More)
- In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E coli evade immune detection after the establishment of bacteriuria. (C) 2008 Elsevier GmbH. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1311443
- author
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Proinflammatory cytokines, Host response, infection, Urinary tract, Fimbriae, Asymptomatic bacteriuria, Escherichia coli
- in
- International Journal of Medical Microbiology
- volume
- 299
- issue
- 1
- pages
- 53 - 63
- publisher
- Elsevier
- external identifiers
-
- wos:000263074400006
- scopus:56949098158
- ISSN
- 1618-0607
- DOI
- 10.1016/j.ijmm.2008.06.003
- language
- English
- LU publication?
- yes
- id
- de9ebdac-5cc9-4029-996e-0a1e19f3ba20 (old id 1311443)
- date added to LUP
- 2016-04-01 11:48:32
- date last changed
- 2022-01-26 18:35:40
@article{de9ebdac-5cc9-4029-996e-0a1e19f3ba20, abstract = {{In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E coli evade immune detection after the establishment of bacteriuria. (C) 2008 Elsevier GmbH. All rights reserved.}}, author = {{Mabbett, Amanda N. and Ulett, Glen C. and Watts, Rebecca E. and Tree, Jai J. and Totsika, Makrina and Ong, Cheryl-lynn Y. and Wood, Jacqueline M. and Monaghan, Wayne and Looke, David F. and Nimmo, Graeme R. and Svanborg, Catharina and Schembri, Mark A.}}, issn = {{1618-0607}}, keywords = {{Proinflammatory cytokines; Host response; infection; Urinary tract; Fimbriae; Asymptomatic bacteriuria; Escherichia coli}}, language = {{eng}}, number = {{1}}, pages = {{53--63}}, publisher = {{Elsevier}}, series = {{International Journal of Medical Microbiology}}, title = {{Virulence properties of asymptomatic bacteriuria Escherichia coli}}, url = {{http://dx.doi.org/10.1016/j.ijmm.2008.06.003}}, doi = {{10.1016/j.ijmm.2008.06.003}}, volume = {{299}}, year = {{2009}}, }