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Incidence of Lower Limb Amputation in the Diabetic and Nondiabetic General Population: A 10-year Population-based Cohort Study of Initial Unilateral, Contralateral and Re-amputations.

Johannesson, Anton LU ; Larsson, Gert-Uno; Ramstrand, Nerrolyn; Turkiewicz, Aleksandra; Wirehn, Ann-Britt and Atroshi, Isam LU (2009) In Diabetes Care 32(2). p.275-280
Abstract
OBJECTIVE - The purpose of this study was to compare the incidence of vascular lower-limb amputation (LLA) in the diabetic and nondiabetic general population. RESEARCH DESIGN AND METHODS - A population-based cohort study was conducted in a representative Swedish region. All vascular LLAs (at or proximal to the transmetatarsal level) performed from 1997 through 2006 were consecutively registered and classified into initial unilateral amputation, contralateral amputation, or reamputation. The incidence rates were estimated in the diabetic and nondiabetic general population aged :45 years. RESULTS - During the 10-year period, LLA was performed on 62 women and 71 men with diabetes and on 79 women and 78 men without diabetes. The incidence of... (More)
OBJECTIVE - The purpose of this study was to compare the incidence of vascular lower-limb amputation (LLA) in the diabetic and nondiabetic general population. RESEARCH DESIGN AND METHODS - A population-based cohort study was conducted in a representative Swedish region. All vascular LLAs (at or proximal to the transmetatarsal level) performed from 1997 through 2006 were consecutively registered and classified into initial unilateral amputation, contralateral amputation, or reamputation. The incidence rates were estimated in the diabetic and nondiabetic general population aged :45 years. RESULTS - During the 10-year period, LLA was performed on 62 women and 71 men with diabetes and on 79 women and 78 men without diabetes. The incidence of initial unilateral amputation per 100,000 person-years was 192 (95% CI 145-241) for diabetic women, 1.97 (152-244) for diabetic men, 22 (17-26) for nondiabetic women, and 24 (19-29) for nondiabetic men. The incidence increased from the age of 75 years. Of all amputations, 74% were transtibial. The incidences of contralateral amputation and of reamputation per 100 amputee-years in diabetic women amputees were 15 (7-27) and 16 (8-28), respectively; in diabetic men amputees 1.8 (10-29) and 21 (12-32); in nondiabetic women amputees 14 (7-24) and is (10-28); and in nondiabetic men amputees 13 (6-22) and 24 (15-35). CONCLUSIONS - In the general population aged >= 45 years, the incidence of vascular LLA at or proximal to the transmetatarsal level is eight. times higher in diabetic than in nondiabetic individuals. One in four amputees may require contralateral amputation and/or reamputation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
32
issue
2
pages
275 - 280
publisher
American Diabetes Association
external identifiers
  • wos:000263018700013
  • scopus:61849115759
  • pmid:19001192
ISSN
1935-5548
DOI
10.2337/dc08-1639
language
English
LU publication?
yes
id
c9dd1465-9f24-4ca8-a910-dfdc7407fbd7 (old id 1311541)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19001192?dopt=Abstract
date added to LUP
2008-12-04 15:15:06
date last changed
2017-12-10 04:21:01
@article{c9dd1465-9f24-4ca8-a910-dfdc7407fbd7,
  abstract     = {OBJECTIVE - The purpose of this study was to compare the incidence of vascular lower-limb amputation (LLA) in the diabetic and nondiabetic general population. RESEARCH DESIGN AND METHODS - A population-based cohort study was conducted in a representative Swedish region. All vascular LLAs (at or proximal to the transmetatarsal level) performed from 1997 through 2006 were consecutively registered and classified into initial unilateral amputation, contralateral amputation, or reamputation. The incidence rates were estimated in the diabetic and nondiabetic general population aged :45 years. RESULTS - During the 10-year period, LLA was performed on 62 women and 71 men with diabetes and on 79 women and 78 men without diabetes. The incidence of initial unilateral amputation per 100,000 person-years was 192 (95% CI 145-241) for diabetic women, 1.97 (152-244) for diabetic men, 22 (17-26) for nondiabetic women, and 24 (19-29) for nondiabetic men. The incidence increased from the age of 75 years. Of all amputations, 74% were transtibial. The incidences of contralateral amputation and of reamputation per 100 amputee-years in diabetic women amputees were 15 (7-27) and 16 (8-28), respectively; in diabetic men amputees 1.8 (10-29) and 21 (12-32); in nondiabetic women amputees 14 (7-24) and is (10-28); and in nondiabetic men amputees 13 (6-22) and 24 (15-35). CONCLUSIONS - In the general population aged >= 45 years, the incidence of vascular LLA at or proximal to the transmetatarsal level is eight. times higher in diabetic than in nondiabetic individuals. One in four amputees may require contralateral amputation and/or reamputation.},
  author       = {Johannesson, Anton and Larsson, Gert-Uno and Ramstrand, Nerrolyn and Turkiewicz, Aleksandra and Wirehn, Ann-Britt and Atroshi, Isam},
  issn         = {1935-5548},
  language     = {eng},
  number       = {2},
  pages        = {275--280},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Incidence of Lower Limb Amputation in the Diabetic and Nondiabetic General Population: A 10-year Population-based Cohort Study of Initial Unilateral, Contralateral and Re-amputations.},
  url          = {http://dx.doi.org/10.2337/dc08-1639},
  volume       = {32},
  year         = {2009},
}