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The Effect of Muscle Loading on Skeletal Muscle Regenerative Potential An Update of Current Research Findings Relating to Aging and Neuromuscular Pathology

Ambrosio, Fabrisia; Kadi, Fawzi; Lexell, Jan LU ; Fitzgerald, G. Kelley; Boninger, Michael L. and Huard, Johnny (2009) In American Journal of Physical Medicine & Rehabilitation 88(2). p.145-155
Abstract
Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the... (More)
Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Exercise, Regeneration, Skeletal Muscle, Stem Cells, Satellite Cells
in
American Journal of Physical Medicine & Rehabilitation
volume
88
issue
2
pages
145 - 155
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000262739900009
  • scopus:59649128291
ISSN
1537-7385
DOI
10.1097/PHM.0b013e3181951fc5
language
English
LU publication?
yes
id
a7afa4dc-3415-4539-9574-76100ad14038 (old id 1312358)
date added to LUP
2009-03-18 08:54:42
date last changed
2017-07-23 04:24:05
@article{a7afa4dc-3415-4539-9574-76100ad14038,
  abstract     = {Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.},
  author       = {Ambrosio, Fabrisia and Kadi, Fawzi and Lexell, Jan and Fitzgerald, G. Kelley and Boninger, Michael L. and Huard, Johnny},
  issn         = {1537-7385},
  keyword      = {Exercise,Regeneration,Skeletal Muscle,Stem Cells,Satellite Cells},
  language     = {eng},
  number       = {2},
  pages        = {145--155},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {American Journal of Physical Medicine & Rehabilitation},
  title        = {The Effect of Muscle Loading on Skeletal Muscle Regenerative Potential An Update of Current Research Findings Relating to Aging and Neuromuscular Pathology},
  url          = {http://dx.doi.org/10.1097/PHM.0b013e3181951fc5},
  volume       = {88},
  year         = {2009},
}