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Moderate mitral regurgitation in patients undergoing CABG - the MoMIC trial

Wierup, Per; Egeblad, Henrik; Nielsen, Sten Lyager; Schersten, Henrik; Kimblad, Per Ola LU ; Bech-Hansen, Odd; Roijer, Anders LU ; Nilsson, Folke; McCarthy, Patrick M. and Bouchard, Denis, et al. (2009) In Scandinavian Cardiovascular Journal1997-01-01+01:00 43(1). p.50-56
Abstract
Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG... (More)
Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
regurgitation, ischemia, Mitral, surgery, trial
in
Scandinavian Cardiovascular Journal1997-01-01+01:00
volume
43
issue
1
pages
50 - 56
publisher
Taylor & Francis
external identifiers
  • wos:000262417100009
  • scopus:61649094298
ISSN
1651-2006
DOI
10.1080/14017430802430950
language
English
LU publication?
yes
id
e05b7207-6c11-4c2d-a349-05fc61433ef6 (old id 1312417)
date added to LUP
2009-03-18 08:55:13
date last changed
2017-08-13 04:06:07
@article{e05b7207-6c11-4c2d-a349-05fc61433ef6,
  abstract     = {Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.},
  author       = {Wierup, Per and Egeblad, Henrik and Nielsen, Sten Lyager and Schersten, Henrik and Kimblad, Per Ola and Bech-Hansen, Odd and Roijer, Anders and Nilsson, Folke and McCarthy, Patrick M. and Bouchard, Denis and Jacobsen, Jacob and Johnsen, Soren Paaske and Poulsen, Steen Hvitfeldt and Molgaard, Henning},
  issn         = {1651-2006},
  keyword      = {regurgitation,ischemia,Mitral,surgery,trial},
  language     = {eng},
  number       = {1},
  pages        = {50--56},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal1997-01-01+01:00},
  title        = {Moderate mitral regurgitation in patients undergoing CABG - the MoMIC trial},
  url          = {http://dx.doi.org/10.1080/14017430802430950},
  volume       = {43},
  year         = {2009},
}